Zemplar Injection (Paricalcitol Injection Fliptop Vial) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 21, 2012

Zemplar

Kidney Failure »

What are the kidneys?

The kidneys play key roles in body function, not only by filtering the blood and getting rid of waste products, but also by balancing levels of electrolyte levels in the body, controlling blood pressure, and stimulating the production of red blood cells.

The kidneys are located in the abdomen toward the back, normally one on each side of the spine. They get their blood supply through the renal arteries directly from the aorta and send blood back to the heart via the renal veins to the vena cava. (The term "renal" is derived from the Latin name for kidney.)

The kidneys have the ability to monitor the amount of body fluid, the concentrations of electrolytes like sodium and potassium, and the acid-base balance of the body. They filter waste products of body metabolism, like urea from protein metabolism and uric acid from DNA breakdown. Two waste products in the blood can be measured: blood urea nitrogen (BUN) ...

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ZEMPLAR®
(paricalcitol) Injection

Fliptop Vial

DRUG DESCRIPTION

Paricalcitol, USP, the active ingredient in Zemplar Injection (paricalcitol injection fliptop vial) , is a synthetically manufactured analog of calcitriol, the metabolically active form of vitamin D indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic kidney disease(CKD) Stage 5. Zemplar is available as a sterile, clear, colorless, aqueous solution for intravenous injection. Each mL contains paricalcitol, 2 mcg or 5 mcg and the following inactive ingredients: alcohol, 20% (v/v) and propylene glycol, 30% (v/v).

Paricalcitol is a white powder chemically designated as 19-nor-1α,3β,25-trihydroxy-9,10-secoergosta5(Z),7(E),22(E)-triene and has the following structural formula:

ZEMPLAR® (paricalcitol) Structural Formula Illustration

Molecular formula is C₂₇H₄₄O₃.

Molecular weight is 416.64.

What are the precautions when taking paricalcitol injection fliptop vial (Zemplar Injection)?

Before taking paricalcitol, tell your doctor or pharmacist if you are allergic to it; or to other vitamin D products; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: high levels of calcium (hypercalcemia), high levels of vitamin D (hypervitaminosis D).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., irregular heartbeat, coronary artery disease), seizures.

During pregnancy, this medication should be used only when clearly...

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Last reviewed on RxList: 5/20/2011
This monograph has been modified to include the generic and brand name in many instances.