Zestoretic (Lisinopril and Hydrochlorothiazide) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 7, 2012

Zestoretic

Kidney Failure »

What are the kidneys?

The kidneys play key roles in body function, not only by filtering the blood and getting rid of waste products, but also by balancing levels of electrolyte levels in the body, controlling blood pressure, and stimulating the production of red blood cells.

The kidneys are located in the abdomen toward the back, normally one on each side of the spine. They get their blood supply through the renal arteries directly from the aorta and send blood back to the heart via the renal veins to the vena cava. (The term "renal" is derived from the Latin name for kidney.)

The kidneys have the ability to monitor the amount of body fluid, the concentrations of electrolytes like sodium and potassium, and the acid-base balance of the body. They filter waste products of body metabolism, like urea from protein metabolism and uric acid from DNA breakdown. Two waste products in the blood can be measured: blood urea nitrogen (BUN) ...

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ZESTORETIC®
(lisinopril and hydrochlorothiazide)

USE IN PREGNANCY

When used in pregnancy, during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, ZESTORETIC (lisinopril and hydrochlorothiazide) should be discontinued as soon as possible (See WARNINGS, Pregnancy, Lisinopril, Fetal/Neonatal Morbidity and Mortality).

DRUG DESCRIPTION

ZESTORETIC® (Lisinopril and Hydrochlorothiazide) combines an angiotensin converting enzyme inhibitor, lisinopril, and a diuretic, hydrochlorothiazide.

Lisinopril, a synthetic peptide derivative, is an oral long-acting angiotensin converting enzyme inhibitor. It is chemically described as (S)-l-[N2-(l-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate. Its empirical formula is C₂₁H₃₁N₃O₅•2H₂O and its structural formula is:

Lisinopril Structural Formula Illustration

Lisinopril is a white to off-white, crystalline powder, with a molecular weight of 441.53. It is soluble in water, sparingly soluble in methanol, and practically insoluble in ethanol.

Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C₇H₈C1N₃O₄S2 and its structural formula is:

Hydrochlorothiazide Structural Formula Illustration

Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.72, which is slightly soluble in water, but freely soluble in sodium hydroxide solution.

ZESTORETIC (lisinopril and hydrochlorothiazide) is available for oral use in three tablet combinations of lisinopril with hydrochlorothiazide: ZESTORETIC (lisinopril and hydrochlorothiazide) 10-12.5 containing 10 mg lisinopril and 12.5 mg hydrochlorothiazide; ZESTORETIC (lisinopril and hydrochlorothiazide) 20-12.5 containing 20 mg lisinopril and 12.5 mg hydrochlorothiazide; and, ZESTORETIC (lisinopril and hydrochlorothiazide) 20-25 containing 20 mg lisinopril and 25 mg hydrochlorothiazide.

Inactive Ingredients

10-12.5 Tablets - calcium phosphate, magnesium stearate, mannitol, red ferric oxide, starch, yellow ferric oxide.

20-12.5 Tablets - calcium phosphate, magnesium stearate, mannitol, starch.

20-25 Tablets - calcium phosphate, magnesium stearate, mannitol, red ferric oxide, starch, yellow ferric oxide.

What are the possible side effects of hydrochlorothiazide and lisinopril (Prinzide, Zestoretic)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
dry...

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What are the precautions when taking lisinopril and hydrochlorothiazide (Zestoretic)?

Before taking this product, tell your doctor or pharmacist if you are allergic to lisinopril or hydrochlorothiazide; or to other ACE inhibitors (such as captopril, benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction that included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), desensitizing treatment for bee/wasp sting allergy, gout, kidney disease, liver disease, collagen vascular disease (such as lupus, scleroderma).

This drug may make you...

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Last reviewed on RxList: 5/2/2011
This monograph has been modified to include the generic and brand name in many instances.