In this Article

• What is hydrochlorothiazide and lisinopril (Zestoretic)?
• What are the possible side effects of hydrochlorothiazide and lisinopril (Zestoretic)?
• What is the most important information I should know about hydrochlorothiazide and lisinopril (Zestoretic)?
• What should I discuss with my healthcare provider before taking hydrochlorothiazide and lisinopril (Zestoretic)?
• How should I take hydrochlorothiazide and lisinopril (Zestoretic)?
• What happens if I miss a dose (Zestoretic)?
• What happens if I overdose (Zestoretic)?
• What should I avoid while taking hydrochlorothiazide and lisinopril (Zestoretic)?
• What other drugs will affect hydrochlorothiazide and lisinopril (Zestoretic)?
• Where can I get more information?

What should I discuss with my healthcare provider before taking hydrochlorothiazide and lisinopril (Zestoretic)?

Do not use this medication if you are unable to urinate.

You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

To make sure you can safely take hydrochlorothiazide and lisinopril, tell your doctor if you have any of these other conditions:

• kidney disease (or if you are on dialysis);
• liver disease;
• glaucoma;
• heart disease or congestive heart failure;
• asthma or allergies;
• gout;
• lupus;
• diabetes; or
• an allergy to sulfa drugs or penicillin.

FDA pregnancy category D. Do not use hydrochlorothiazide and lisinopril if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Lisinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking hydrochlorothiazide and lisinopril.

Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take hydrochlorothiazide and lisinopril (Zestoretic)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Take each dose with a full glass of water.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and lisinopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Your blood pressure will need to be checked often. Visit your doctor regularly.

Your blood and urine may also be tested if you have been vomiting or are dehydrated.

Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture, heat, and light.