Brand Names: Prinzide, Zestoretic

Generic Name: hydrochlorothiazide and lisinopril (Pronunciation: HYE droe KLOR oh THYE a zide and lye SIN oh pril)

• What is hydrochlorothiazide and lisinopril (Zestoretic)?
• What are the possible side effects of hydrochlorothiazide and lisinopril (Zestoretic)?
• What is the most important information I should know about hydrochlorothiazide and lisinopril (Zestoretic)?
• What should I discuss with my healthcare provider before taking hydrochlorothiazide and lisinopril (Zestoretic)?
• How should I take hydrochlorothiazide and lisinopril (Zestoretic)?
• What happens if I miss a dose (Zestoretic)?
• What happens if I overdose (Zestoretic)?
• What should I avoid while taking hydrochlorothiazide and lisinopril (Zestoretic)?
• What other drugs will affect hydrochlorothiazide and lisinopril (Zestoretic)?
• Where can I get more information?

What is hydrochlorothiazide and lisinopril (Zestoretic)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Lisinopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention.

The combination of hydrochlorothiazide and lisinopril is used to treat hypertension (high blood pressure).

Hydrochlorothiazide and lisinopril may also be used for other purposes not listed in this medication guide.

HCT-Lisinopril 12.5 mg-10 mg-RAN

round, blue, imprinted with RX 536

HCT-Lisinopril 12.5 mg-20 mg-RAN

round, yellow, imprinted with RX 537

HCT-Lisinopril 25 mg-20 mg-GG

round, peach, imprinted with GP 123

HCT-Lisinopril 25 mg-20 mg-RAN

round, peach, imprinted with RX 538

HCTZ-Lisinopril 12.5 mg-10 mg-IVA

round, blue, imprinted with 10/12.5, Logo 5033

HCTZ-Lisinopril 12.5 mg-10 mg-TEV

round, peach, imprinted with 93, 1035

HCTZ-Lisinopril 12.5 mg-20 mg-IVA

round, yellow, imprinted with 20/12.5, Logo 5034

HCTZ-Lisinopril 12.5 mg-20 mg-TEV

round, white, imprinted with 93, 1036

HCTZ-Lisinopril 25 mg-20 mg-IVA

round, peach, imprinted with 20/25, Logo 5032

HCTZ-Lisinopril 25 mg-20 mg-TEV

round, pink, imprinted with 93, 1037

Lisinopril-HCTZ 10-12.5 mg-EON

round, pink, imprinted with E 71

Lisinopril-HCTZ 10-12.5 mg-MYL

round, white, imprinted with M, LH1

Lisinopril-HCTZ 10-12.5 mg-WAT

round, pink, imprinted with WATSON 860

Lisinopril-HCTZ 20-12.5 mg-EON

round, white, imprinted with E 152

Lisinopril-HCTZ 20-12.5 mg-MYL

round, yellow, imprinted with M, LH2

Lisinopril-HCTZ 20-12.5 mg-WAT

round, blue, imprinted with WATSON 861

Lisinopril-HCTZ 20-25 mg-EON

round, pink, imprinted with E 173

Lisinopril-HCTZ 20-25 mg-MYL

round, green, imprinted with M, LH3

Lisinopril-HCTZ 20-25 mg-WAT

round, pink, imprinted with WATSON 862

Prinizide 12.5 mg-10 mg

hexagonal, white, imprinted with PRINZIDE, MSD 145

Prinizide 12.5 mg-20 mg

round, yellow, imprinted with MSD 140, PRINZIDE

Prinzide 20-25 mg

round, yellow, imprinted with PRINZIDE, MSD 142

Zestoretic 10-12.5

round, peach, imprinted with ZESTORETIC, 141

Zestoretic 20-12.5

round, white, imprinted with ZESTORETIC, 142

Zestoretic 20-25

round, peach, imprinted with ZESTORETIC, 145

What are the possible side effects of hydrochlorothiazide and lisinopril (Zestoretic)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);
• low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
• dry mouth, thirst, nausea, vomiting;
• feeling weak, drowsy, restless, or light-headed;
• a red, blistering, peeling skin rash;
• jaundice (yellowing of the skin or eyes);
• urinating less than usual or not at all;
• swelling, weight gain, feeling short of breath; or
• fever, chills, body aches, flu symptoms.

Less serious side effects may include:

• cough;
• dizziness, tired feeling, depressed mood;
• headache, blurred vision;
• diarrhea, constipation, upset stomach; or
• mild skin rash, increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrochlorothiazide and lisinopril (Zestoretic)?

Do not use this medication if you are unable to urinate.

You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

Before taking hydrochlorothiazide and lisinopril, tell your doctor if you have kidney disease (or are on dialysis), liver disease, congestive heart failure, gout, lupus, diabetes, or an allergy to sulfa drugs.

Lisinopril can cause birth defects in the baby if you take the medication during pregnancy. Do not use hydrochlorothiazide and lisinopril without telling your doctor if you are pregnant or planning a pregnancy.

Avoid the regular use of salt substitutes in your diet, and do not take potassium supplements while taking hydrochlorothiazide and lisinopril, unless your doctor has told you to.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking other diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and lisinopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.