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Zestril

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Zestril

Zestril®
(lisinopril) Tablets

WARNING

FETAL TOXICITY

  • When pregnancy is detected, discontinue Zestril as soon as possible [see WARNINGS AND PRECAUTIONS].
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus [see WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION

Lisinopril is an oral long-acting angiotensin converting enzyme (ACE) inhibitor. Lisinopril, a synthetic peptide derivative, is chemically described as (S)-1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate. Its empirical formula is C21H31N3O52H2O and its structural formula is:

Zestril® (lisinopril) Structural Formula Illustration

Lisinopril is a white to off-white, crystalline powder, with a molecular weight of 441.53. It is soluble in water and sparingly soluble in methanol and practically insoluble in ethanol.

Zestril is supplied as 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg and 40 mg tablets for oral administration.

Inactive Ingredients:

2.5 mg tablets -calcium phosphate, magnesium stearate, mannitol, starch.

5, 10, 20 and 30 mg tablets -calcium phosphate, magnesium stearate, mannitol, red ferric oxide, starch.

40 mg tablets -calcium phosphate, magnesium stearate, mannitol, starch, yellow ferric oxide.

What are the possible side effects of lisinopril (Prinivil, Zestril)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • feeling like you might pass out;
  • urinating more or less than usual, or not at all;
  • fever, chills, body aches, flu symptoms;
  • tired feeling, muscle weakness, and pounding or uneven heartbeats;
  • chest pain; or
  • swelling, rapid weight gain.

Less serious side effects may...

Read All Potential Side Effects and See Pictures of Zestril »

What are the precautions when taking lisinopril (Zestril)?

Before taking lisinopril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, collagen vascular disease (such as lupus, scleroderma).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are...

Read All Potential Precautions of Zestril »

Last reviewed on RxList: 7/14/2014
This monograph has been modified to include the generic and brand name in many instances.

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Zestril - User Reviews

Zestril User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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