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Ziac

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Ziac

ZIAC®
(bisoprolol fumarate and hydrochlorothiazide) Tablets

DRUG DESCRIPTION

ZIAC® (bisoprolol fumarate and hydrochlorothiazide) is indicated for the treatment of hypertension. It combines two antihypertensive agents in a once-daily dosage: a synthetic betar selective (cardioselective) adrenoceptor blocking agent (bisoprolol fumarate) and a benzothiadiazine diuretic (hydrochlorothiazide).

Bisoprolol fumarate is chemically described as (±)-l-[4-[[2-(l- methylethoxy)ethoxy]methyl]phenoxy]-3-[(l-methylethyl)amino]-2-propanol(E)-2-butenedioate (2:1) (salt). It possesses an asymmetric carbon atom in its structure and is provided as a racemic mixture. The S(-) enantiomer is responsible for most of the beta-blocking activity. Its empirical formula is (C18H31NO4)2•C4H4O4 and it has a molecular weight of 766.97. Its structural formula is:

Bisoprolol fumarate Structural Formula Illustration

Bisoprolol fumarate is a white crystalline powder, approximately equally hydrophilic and lipophilic, and readily soluble in water, methanol, ethanol, and chloroform.

Hydrochlorothiazide (HCTZ) is 6-Chloro-3,4-dihydro-2H-l,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. It is a white, or practically white, practically odorless crystalline powder. It is slightly soluble in water, sparingly soluble in dilute sodium hydroxide solution, freely soluble in n-butylamine and dimethylformamide, sparingly soluble in methanol, and insoluble in ether, chloroform, and dilute mineral acids. Its empirical formula is C7H8ClN3O4S2 and it has a molecular weight of 297.73. Its structural formula is:

Hydrochlorothiazide Structural Formula Illustration

Each ZIAC®-2.5 mg/6.25 mg tablet for oral administration contains:

Bisoprolol fumarate................................2.5 mg
Hydrochlorothiazide...............................6.25 mg

Each ZIAC®-5 mg/6.25 mg tablet for oral administration contains:

Bisoprolol fumarate................................5 mg
Hydrochlorothiazide...............................6.25 mg

Each ZIAC®-10 mg/6.25 mg tablet for oral administration contains:

Bisoprolol fumarate................................10 mg
Hydrochlorothiazide...............................6.25 mg

Inactive ingredients include Corn Starch, Dibasic Calcium Phosphate, Hypromellose, Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polysorbate 80, and Titanium Dioxide. The 10 mg/6.25 mg tablet also contains Colloidal Silicon Dioxide. The 5 mg/6.25 mg tablet also contains Colloidal Silicon Dioxide, and Red and Yellow Iron Oxide. The 2.5 mg/6.25 mg tablet also contains Crospovidone, Pregelatinized Starch, and Yellow Iron Oxide.

What are the possible side effects of hydrochlorothiazide and bisoprolol (Ziac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • eye pain, vision problems;
  • swelling, rapid weight gain, feeling short of breath, even with mild exertion;
  • fast, slow, or uneven heartbeat;
  • easy bruising or bleeding;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe...

Read All Potential Side Effects and See Pictures of Ziac »

What are the precautions when taking bisoprolol and hydrochlorothiazide (Ziac)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to bisoprolol or hydrochlorothiazide; or to other beta blockers (e.g., metoprolol, atenolol); or to other thiazide diuretics (e.g., chlorothiazide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems (e.g., sinus bradycardia, second- or third-degree atrioventricular block), certain serious heart conditions (cardiogenic shock, severe heart failure), inability to urinate...

Read All Potential Precautions of Ziac »

Last reviewed on RxList: 8/16/2011
This monograph has been modified to include the generic and brand name in many instances.

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Ziac - User Reviews

Ziac User Reviews

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Hypertension

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