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ZIAC® (bisoprolol fumarate and hydrochlorothiazide) is indicated for the treatment of hypertension. It combines two antihypertensive agents in a once-daily dosage: a synthetic betar selective (cardioselective) adrenoceptor blocking agent (bisoprolol fumarate) and a benzothiadiazine diuretic (hydrochlorothiazide).

Bisoprolol fumarate is chemically described as (±)-l-[4-[[2-(l- methylethoxy)ethoxy]methyl]phenoxy]-3-[(l-methylethyl)amino]-2-propanol(E)-2-butenedioate (2:1) (salt). It possesses an asymmetric carbon atom in its structure and is provided as a racemic mixture. The S(-) enantiomer is responsible for most of the beta-blocking activity. Its empirical formula is (C₁₈H₃₁NO₄)₂•C₄H₄O₄ and it has a molecular weight of 766.97. Its structural formula is:

Bisoprolol fumarate is a white crystalline powder, approximately equally hydrophilic and lipophilic, and readily soluble in water, methanol, ethanol, and chloroform.

Hydrochlorothiazide (HCTZ) is 6-Chloro-3,4-dihydro-2H-l,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. It is a white, or practically white, practically odorless crystalline powder. It is slightly soluble in water, sparingly soluble in dilute sodium hydroxide solution, freely soluble in n-butylamine and dimethylformamide, sparingly soluble in methanol, and insoluble in ether, chloroform, and dilute mineral acids. Its empirical formula is C₇H₈ClN₃O₄S₂ and it has a molecular weight of 297.73. Its structural formula is:

Each ZIAC®-2.5 mg/6.25 mg tablet for oral administration contains:

Bisoprolol fumarate................................2.5 mg
Hydrochlorothiazide...............................6.25 mg

Each ZIAC®-5 mg/6.25 mg tablet for oral administration contains:

Bisoprolol fumarate................................5 mg
Hydrochlorothiazide...............................6.25 mg

Each ZIAC®-10 mg/6.25 mg tablet for oral administration contains:

Bisoprolol fumarate................................10 mg
Hydrochlorothiazide...............................6.25 mg

Inactive ingredients include Corn Starch, Dibasic Calcium Phosphate, Hypromellose, Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polysorbate 80, and Titanium Dioxide. The 10 mg/6.25 mg tablet also contains Colloidal Silicon Dioxide. The 5 mg/6.25 mg tablet also contains Colloidal Silicon Dioxide, and Red and Yellow Iron Oxide. The 2.5 mg/6.25 mg tablet also contains Crospovidone, Pregelatinized Starch, and Yellow Iron Oxide.

Last reviewed on RxList: 8/16/2011
This monograph has been modified to include the generic and brand name in many instances.