Brand Names: Ziac

Generic Name: hydrochlorothiazide and bisoprolol (Pronunciation: HYE droe klor oh THYE a zide and bi SOE proe lol)

• What is hydrochlorothiazide and bisoprolol (Ziac)?
• What are the possible side effects of hydrochlorothiazide and bisoprolol (Ziac)?
• What is the most important information I should know about hydrochlorothiazide and bisoprolol (Ziac)?
• What should I discuss with my doctor before taking hydrochlorothiazide and bisoprolol (Ziac)?
• How should I take hydrochlorothiazide and bisoprolol (Ziac)?
• What happens if I miss a dose (Ziac)?
• What happens if I overdose (Ziac)?
• What should I avoid while taking hydrochlorothiazide and bisoprolol (Ziac)?
• What other drugs will affect hydrochlorothiazide and bisoprolol (Ziac)?
• Where can I get more information?

What is hydrochlorothiazide and bisoprolol (Ziac)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Bisoprolol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

The combination of hydrochlorothiazide and bisoprolol is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and bisoprolol may also be used for other purposes not listed in this medication guide.

Bisoprolol-HCT 10 mg-6.25 mg-PUR

oblong, white, imprinted with 652, R

Bisoprolol-HCT 10 mg-6.25 mg-WAT

round, white, imprinted with 843, WATSON

Bisoprolol-HCT 2.5 mg-6.25 mg-WAT

round, yellow, imprinted with 841, WATSON

Bisoprolol-HCT 5 mg-6.25 mg-WAT

round, pink, imprinted with 842, WATSON

Bisoprolol-HCTZ 10 mg-6.25 mg-EON

round, white, imprinted with E 707

Bisoprolol-HCTZ 10-6.25 mg-MYL

round, white, imprinted with 505, M

Bisoprolol-HCTZ 2.5 mg-6.25 mg-EON

round, peach, imprinted with E 701

Bisoprolol-HCTZ 2.5-6.25 mg-MYL

round, orange, imprinted with 501, M

Bisoprolol-HCTZ 5 mg-6.25 mg-EON

round, red, imprinted with E 704

Bisoprolol-HCTZ 5-6.25 mg-MYL

round, blue, imprinted with 503, M

Ziac 10 mg

round, white, imprinted with LL, B 14

Ziac 10 mg-BAR

round, white, imprinted with b, 40

Ziac 2.5 mg

round, yellow, imprinted with LL, B 12

Ziac 2.5 mg-BAR

round, yellow, imprinted with b, 47

Ziac 5 mg

round, pink, imprinted with LL, B 13

Ziac 5 mg-BAR

round, pink, imprinted with b, 50

What are the possible side effects of hydrochlorothiazide and bisoprolol (Ziac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

• swelling, rapid weight gain, feeling short of breath, even with mild exertion;
• fast, slow, or uneven heartbeat;
• chest pain;
• easy bruising or bleeding;
• sudden numbness or weakness on one side of the body, problems with vision or speech, chest pain, or pain in one or both legs;
• numbness or tingly feeling in your hands or feet;
• feeling weak, drowsy, restless, or light-headed;
• nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions);
• increased urination, leg discomfort, muscle pain or weakness or limp feeling;
• urinating less than usual or not at all;
• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
• upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• diarrhea, constipation, upset stomach;
• headache, tired feeling;
• dizziness, spinning sensation;
• cough, runny nose;
• ringing in your ears; or
• blurred vision.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrochlorothiazide and bisoprolol (Ziac)?

You should not use this medication if you have severe or uncontrolled heart failure, a heart condition called "sick sinus syndrome" or "AV block," an allergy to sulfa drugs, or if you are unable to urinate.

Before using this medication, tell your doctor if you have kidney or liver disease, cirrhosis, asthma, allergies, gout, lupus, diabetes, or a thyroid disorder.

If you are diabetic, check your blood sugar carefully. Using bisoprolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and bisoprolol. Talk with your doctor before changing any doses.

Avoid drinking alcohol, which can lower your blood pressure and may add to the side effects of hydrochlorothiazide and bisoprolol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Keep using this medication even if you feel fine. High blood pressure often has no symptoms.

There are many other medicines that can interact with hydrochlorothiazide and bisoprolol. Tell your doctor about all the prescription and over-the-counter medications you use.