Zinc

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Are there any interactions with medications?



Penicillamine
Interaction Rating: Major Do not take this combination.

Penicillamine is used for Wilson's disease and rheumatoid arthritis. Zinc might decrease how much penicillamine your body absorbs and decrease the effectiveness of penicillamine. Take zinc and penicillamine at least 2 hours apart.



Antibiotics (Quinolone antibiotics)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Zinc might decrease how much antibiotic the body absorbs. Taking zinc along with some antibiotics might decrease the effectiveness of some antibiotics. To avoid this interaction, take antibiotics at least 2 hours before or 4-6 hours after zinc supplements.

Some of these antibiotics that might interact with zinc include ciprofloxacin (Cipro), levofloxacin (Levaquin), ofloxacin (Floxin), moxifloxacin (Avelox), gatifloxacin (Tequin) enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).



Antibiotics (Tetracycline antibiotics)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Zinc can attach to tetracyclines in the stomach. This decreases the amount of tetracyclines that can be absorbed. Taking zinc with tetracyclines might decrease the effectiveness of tetracyclines. To avoid this interaction, take tetracyclines 2 hours before or 4-6 hours after taking zinc supplements.

Some tetracyclines include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin, Sumycin).



Cisplatin (Platinol-AQ)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Cisplatin (Platinol-AQ) is used to treat cancer. Taking zinc along with EDTA and cisplatin (Platinol-AQ) might inactivate cisplatin (Platinol-AQ) therapy. It is not known for sure, though, if the amount of interference caused by zinc is significant.



Amiloride (Midamor)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Amiloride (Midamor) is used as a "water pill" to help remove excess water from the body. Another effect of amiloride (Midamor) is that it can increase the amount of zinc in the body. Taking zinc supplements with amiloride (Midamor) might cause you to have too much zinc in your body.

Dosing considerations for Zinc.

The following doses have been studied in scientific research:

BY MOUTH:
  • For treating the common cold: one zinc gluconate or acetate lozenge, providing 9-24 mg elemental zinc, dissolved in the mouth every two hours while awake when cold symptoms are present.
  • For diarrhea in malnourished or zinc-deficient children: 10-40 mg elemental zinc daily.
  • For preventing and treating pneumonia in undernourished children in developing countries: 10-70 mg/day.
  • For hypogeusia (sense of taste is abnormal): 25-100 mg zinc.
  • For the eating disorder anorexia nervosa: 100 mg of zinc gluconate daily.
  • For treating stomach ulcers: zinc sulfate 200 mg three times daily.
  • For muscle cramps in zinc deficient people with liver disease: zinc sulfate 220 mg twice daily.
  • For osteoporosis: 15 mg zinc combined with 5 mg manganese, 1000 mg calcium, and 2.5 mg copper has been used.
  • For sickle cell disease: zinc sulfate 220 mg three times daily.
  • To increase growth and weight gain in children with sickle cell disease who have not reached puberty: 10 mg elemental zinc per day.
  • For treating attention deficit-hyperactivity disorder (ADHD) in children: doses of zinc sulfate 55 mg (15 mg elemental zinc) to 150 mg (40 mg elemental zinc) daily.
  • For treating acne: 30-135 mg elemental zinc daily.
  • For treating age-related macular degeneration (AMD): elemental zinc 80 mg plus vitamin C 500 mg, vitamin E 400 IU, and beta-carotene 15 mg daily.
The Institute of Medicine has established Adequate Intake (AI) levels of zinc for infants birth to 6 months is 2 mg/day. For older infants, children, and adults, Recommended Dietary Allowance (RDA) quantities of zinc have been established: infants and children 7 months to 3 years, 3 mg/day; 4 to 8 years, 5 mg/day; 9 to 13 years, 8 mg/day; girls 14 to 18 years, 9 mg/day; boys and men age 14 and older, 11 mg/day; women 19 and older, 8 mg/day; pregnant women 14 to 18, 13 mg/day; pregnant women 19 and older, 11 mg/day; lactating women 14 to 18, 14 mg/day; lactating women 19 and older, 12 mg/day.

The typical North American male consumes about 13 mg/day of dietary zinc; women consume approximately 9 mg/day.

The Tolerable Upper Intake Levels (UL) of zinc for people who are not receiving zinc under medical supervision: Infants birth to 6 months, 4 mg/day; 7 to 12 months, 5 mg/day; children 1 to 3 years, 7 mg/day; 4 to 8 years, 12 mg/day; 9 to 13 years, 23 mg/day; 14 to 18 years (including pregnancy and lactation), 34 mg/day; adults 19 years and older (including pregnancy and lactation), 40 mg/day.

Different salt forms provide different amounts of elemental zinc. Zinc sulfate contains 23% elemental zinc; 220 mg zinc sulfate contains 50 mg zinc. Zinc gluconate contains 14.3% elemental zinc; 10 mg zinc gluconate contains 1.43 mg zinc.

APPLIED TO THE SKIN:
  • For acne vulgaris: zinc acetate 1.2% with erythromycin 4% as a lotion applied twice daily.
  • For herpes simplex infections: zinc sulfate 0.25% applied 8 to 10 times daily or zinc oxide 0.3% with glycine applied every 2 hours while awake.

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