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IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

DEXRAZOXANE - INJECTION

(dex-razz-OX-ane)

COMMON BRAND NAME(S): Zinecard

USES: This medication is used to reduce the risk of heart damage from doxorubicin, an anticancer medication. Dexrazoxane is known as a chelating agent. It is believed to work by preventing the release of certain chemicals (iron-mediated free radicals) in the body. These chemicals are thought to be part of the reason why doxorubicin (and similar drugs known as anthracyclines) causes damage to the heart. Dexrazoxane also allows your oncologist (cancer doctor) to treat you longer with doxorubicin as part of your cancer treatment.

The manufacturer recommends that dexrazoxane should not be given with the first dose of doxorubicin. It is believed that the beneficial effects of doxorubicin may be decreased if it is given with the first dose of doxorubicin. Talk to your oncologist for more details.

HOW TO USE: This medication is given by injection into a vein by a health care professional. It is started no more than 30 minutes before a dose of doxorubicin. It is given by either slow IV push or rapid infusion from an infusion bag.

Dosage is based on your dose of doxorubicin and your medical condition, body size, and response to treatment. If your doxorubicin dose is changed, your dexrazoxane will also need to be changed. Follow your doctor's directions exactly.

If skin contact occurs, flush with plenty of soap and water. If irritation occurs, contact your doctor immediately.

Use this medication before each dose of doxorubicin (after your first dose) to get the most benefit from it.

Symptoms of heart damage may occur when you first receive doxorubicin, during later doses of doxorubicin, or years after the end of your doxorubicin treatment. It is important to continue using this medication even if you do not have symptoms of heart damage such as sudden nighttime shortness of breath, difficulty breathing while lying down, or shortness of breath when active.