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In adults following a single administration of ZINGO® the plasma levels of lidocaine were below the limit of detection (5 ng/ml). Signs of central nervous system (CNS) toxicity may start a plasma concentrations of lidocaine as low as 1000 ng/ml, and the risk of seizures generally increases with increasing plasma levels. Very high levels of lidocaine can cause respiratory arrest, coma, decreases in cardiac output, total peripheral resistance, and mean arterial pressure, ventricular arrhythmias, and cardiac arrest. The toxicity of coadminsitered local anesthetics is thought to be at least additive. In the absence of massive topical overdose or oral ingestion, other etiologies for the clinical effects or overdosage from other sources of lidocaine or other local anesthetics should be considered. The management of overdosage includes close monitoring, supportive care, and symptomatic treatment. Dialysis is of negligible value in the treatment of acute overdosage of lidocaine.
ZINGO® is contraindicated in patients with a known history of sensitivity to local anesthetics of the amide type.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/5/2016
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