"July 13, 2015 -- Pyrethroids are chemicals commonly used in products aimed at killing insects, head lice, and fleas on pets. They were created to replace now-banned chemicals in insecticides and other products.
But new research is raising "...
In adults following a single administration of Zingo™ (lindocaine hydrochloride monohydrate) the plasma levels of lidocaine were below the limit of detection (5 ng/mL). Signs of central nervous system (CNS) toxicity may start at plasma concentrations of lidocaine as low as 1000 ng/mL, and the risk of seizures generally increases with increasing plasma levels. Very high levels of lidocaine can cause respiratory arrest, coma, decreases in cardiac output, total peripheral resistance, and mean arterial pressure, ventricular arrhythmias, and cardiac arrest. The toxicity of coadministered local anesthetics is thought to be at least additive. In the absence of massive topical overdose or oral ingestion, other etiologies for the clinical effects or overdosage from other sources of lidocaine or other local anesthetics should be considered. The management of overdosage includes close monitoring, supportive care, and symptomatic treatment. Dialysis is of negligible value in the treatment of acute overdosage of lidocaine.
Zingo™ (lindocaine hydrochloride monohydrate) is contraindicated in patients with a known history of sensitivity to local anesthetics of the amide type.
Last reviewed on RxList: 2/27/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Zingo Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Parenting and Pregnancy
Get tips for baby and you.