November 28, 2015
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(tafluprost) Ophthalmic Solution


Tafluprost is a fluorinated analog of prostaglandin F2α. The chemical name for tafluprost is 1-methylethyl (5Z)-7{(1R, 2R, 3R, 5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-butenyl}-3,5-dihydroxycyclopentyl]-5-heptenoate. The molecular formula of tafluprost is C25H34F2O5 and its molecular weight is 452.53.

Its structural formula is:

ZIOPTAN® (tafluprost) Structural Formula Illustration

Tafluprost is a colorless to light yellow viscous liquid that is practically insoluble in water.

ZIOPTAN® (tafluprost ophthalmic solution) 0.0015% is supplied as a sterile solution of tafluprost with a pH range of 5.5 to 6.7 and an Osmolality range of 260 to 300 mOsmol/kg.

ZIOPTAN® contains Active: tafluprost 0.015 mg/mL; Inactives: glycerol, sodium dihydrogen phosphate dihydrate, disodium edetate, polysorbate 80, hydrochloric acid and/or sodium hydroxide (to adjust pH) and Water for Injection.

ZIOPTAN® does not contain a preservative.

Last reviewed on RxList: 9/18/2015
This monograph has been modified to include the generic and brand name in many instances.

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