"A class of medications long used to curb HIV infection shows promise as a therapy for age-related macular degeneration (AMD), suggest findings from an NIH-funded study. These mainstay HIV drugs, called nucleoside reverse transcriptase inhibitors "...
(ganciclovir) Ophthalmic Gel 0.15%
ZIRGAN (ganciclovir ophthalmic gel) 0.15% contains a sterile, topical antiviral for ophthalmic use. The chemical name is 9-[[(2-hydroxy-1 -(hydroxymethyl) ethoxy] methyl] guanine (CAS number 82410-32-0). Ganciclovir is represented by the following structural formula:
Ganciclovir has a molecular weight of 255.23, and the empirical formula is C9H13N5O4. Each gram of gel contains: ACTIVE: ganciclovir 1.5 mg (0.15%). INACTIVES: carbopol, water for injection, sodium hydroxide (to adjust the pH to 7.4), mannitol. PRESERVATIVE: benzalkonium chloride 0.075 mg.
What are the possible side effects of ganciclovir (Vitrasert, Zirgan)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- eye pain, swelling, redness, or watering;
- severe burning or itching of your eyes;
- vision changes, increased sensitivity to light;
- tunnel vision, problems with peripheral (side) vision;
- seeing flashes of light, halos around lights, or "floaters" in your vision;
- white patches on your...
What are the precautions when taking ganciclovir ophthalmic gel (Zirgan)?
Before using ganciclovir, tell your doctor or pharmacist if you are allergic to it; or to valganciclovir; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history.
This drug may cause temporary blurred vision after each application. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should...
Last reviewed on RxList: 9/30/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Zirgan Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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