August 29, 2016
Recommended Topic Related To:


"The U.S. Food and Drug Administration today approved Differin Gel 0.1% (adapalene), a once-daily topical gel for the over-the-counter (OTC) treatment of acne. Differin Gel 0.1% is approved for use in people 12 years of age and older.




Zoderm Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/16/2016

Zoderm (5.75% benzoyl peroxide) is a combination of an antibacterial medication that also has a mild drying effect, and an emollient (skin softening agent) used to treat acne. Zoderm is available in generic form. Common side effects of Zoderm include:

  • skin burning
  • stinging
  • tingling
  • warmth
  • itching
  • redness
  • dryness
  • peeling
  • swelling, or
  • irritation of the treated area

Wash affected areas once or twice a day, or as directed by your dermatologist. Wet skin and liberally apply a dose of Zoderm to areas to be cleansed, massage gently into skin for 10-20 seconds, working into a full lather, rinse thoroughly and pat dry. Zoderm may interact with tretinoin, other topical products used on the same area at the same time, or harsh, abrasive, or irritating cleansers, perfumes, or cosmetics on the area being treated. Tell your doctor all medications and supplements you use. It is unknown if Zoderm will be harmful to a fetus. Talk to your doctor if you are pregnant or could become pregnant during treatment. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Zoderm (5.75% benzoyl peroxide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Zoderm in Detail - Patient Information: Side Effects

Serious side effects are not likely to occur. Stop using benzoyl peroxide and urea topical and seek emergency medical attention if you experience a rare but serious allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives).

Some skin burning, stinging, tingling, itching, redness, dryness, peeling, or irritation of the treated area may be experienced while using benzoyl peroxide and urea topical. Contact your doctor if these side effects are excessive. Less frequent application of benzoyl peroxide and urea topical may be necessary.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Zoderm (5.75 Benzoyl Peroxide)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Zoderm FDA Prescribing Information: Side Effects
(Adverse Reactions)


Allergic contact dermatitis and dryness have been reported with topical Benzoyl Peroxide therapy.

Read the entire FDA prescribing information for Zoderm (5.75 Benzoyl Peroxide)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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