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Zofran

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Zofran

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Zofran Drug Center

Medical Editor: Eni Williams, PharmD, PhD

Zofran (Ondansetron) is a medication that belongs to the drug class known as antiemetic and selective 5-HT3 receptor antagonist. Zofran is prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Common side effects of Zofran include diarrhea, headache, fever, lightheadedness, dizziness, drowsiness, constipation, rash, blurred vision and muscle spasm.

Zofran adult dose is 32-mg given as a single dose or divided in three 0.15-mg/kg divided doses infused over 15 minutes. Drug interactions include Ultram (tramadol) and cytochrome P-450 enzyme inhibitors or inducers including Dilantin (phenytoin), Tegretol (carbamazepine), and rifadin (rifampin). Zofran should not be used during pregnancy unless the benefits outweigh the risks. It is not known if Zofran is excreted in breast milk.

Our Zofran Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements and disease and conditions.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Zofran Prescribing Information: Indications & Dosage

ZOFRAN®
  (ondansetron hydrochloride) Structural Formula Illustration
  1. Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin ≥ 50 mg/m2.
  2. Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy.
  3. Prevention of nausea and vomiting associated with radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen.
  4. Prevention of postoperative nausea and/or vomiting. As with other antiemet...

Read the complete drug monograph for Zofran »

What is Patient information?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Zofran Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • blurred vision or temporary blindness;
  • fever;
  • slow heart rate, trouble breathing;
  • anxiety, agitation, shivering;
  • feeling light-headed, fainting; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • diarrhea or constip...

Read the complete patient information for Zofran »

What is Consumer information?

A concise overview of the drug for the patient or caregiver from First DataBank.

Zofran Consumer Information: Uses

This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.

HOW TO USE: To prevent nausea from chemotherapy, take this medication by mouth usually within 30 minutes before treatment begins. To prevent nausea from radiation treatment, take this medication by mouth 1 to 2 hours before the start ...

Read the complete consumer information for Zofran »

What is Zofran Consumer Information?

Warnings - Uses - How to Use - Side Effects - Precautions - Drug Interactions and More

Zofran - User Reviews

Zofran User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Zofran sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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