Brand Names: Zofran, Zofran ODT

Generic Name: ondansetron (Pronunciation: on DAN se tron)

• What is ondansetron (Zofran)?
• What are the possible side effects of ondansetron (Zofran)?
• What is the most important information I should know about ondansetron (Zofran)?
• What should I discuss with my health care provider before taking ondansetron (Zofran)?
• How should I take ondansetron (Zofran)?
• What happens if I miss a dose (Zofran)?
• What happens if I overdose (Zofran)?
• What should I avoid while taking ondansetron (Zofran)?
• What other drugs will affect ondansetron (Zofran)?
• Where can I get more information?

What is ondansetron (Zofran)?

Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation).

Ondansetron may also be used for other purposes not listed in this medication guide.

Ondansetron 4 mg ODT-MYL

round, white, imprinted with M, 732

Ondansetron 8 mg ODT-MYL

round, white, imprinted with M, 734

Zofran 4 mg

oval, white, imprinted with Zofran, 4

Zofran 8 mg

oval, yellow, imprinted with Zofran, 8

What are the possible side effects of ondansetron (Zofran)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• blurred vision or temporary blindness;
• fever;
• slow heart rate, trouble breathing;
• anxiety, agitation, shivering;
• feeling light-headed, fainting; or
• urinating less than usual or not at all.

Less serious side effects may include:

• diarrhea or constipation;
• weakness or tired feeling;
• headache;
• dizziness or drowsiness;

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ondansetron (Zofran)?

Do not use this medication if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).

Before taking ondansetron, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome.

Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

The serious side effects of this medication include blurred vision or temporary blindness, slow heart rate, trouble breathing, anxiety, agitation, shivering, feeling light-headed, or fainting, and urinating less than usual or not at all. Stop taking ondansetron and call your doctor at once if you have any of these side effects.

Ondansetron can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.