"May 4, 2011 -- The osteoporosis drugs known as bisphosphonates increase the risk of getting unusual thigh bone fractures, as experts have suspected, according to a new Swedish study.
But these fractures are infrequent and the risk is "...
- Patients should be instructed to tell their doctor if they have kidney problems before being given Zometa.
- Patients should be informed of the importance of getting their blood tests (serum creatinine) during the course of their Zometa therapy.
- Zometa should not be given if the patient is pregnant or plans to become pregnant, or if she is breastfeeding.
- Patients should be advised to have a dental examination prior to treatment with Zometa and should avoid invasive dental procedures during treatment.
- Patients should be informed of the importance of good dental hygiene and routine dental care.
- Patients with multiple myeloma and bone metastasis of solid tumors should be advised to take an oral calcium supplement of 500 mg and a multiple vitamin containing 400 international units of Vitamin D daily.
- Patients should be advised to report any thigh, hip, or groin pain. It is unknown whether the risk of atypical femur fracture continues after stopping therapy.
- Patients should be aware of the most common side effects including: anemia, nausea, vomiting, constipation, diarrhea, fatigue, fever, weakness, lower limb edema, anorexia, decreased weight, bone pain, myalgia, arthralgia, back pain, malignant neoplasm aggravated, headache, dizziness, insomnia, paresthesia, dyspnea, cough, and abdominal pain.
- There have been reports of bronchoconstriction in aspirin-sensitive patients receiving bisphosphonates, including zoledronic acid. Before being given zoledronic acid, patients should tell their doctor if they are aspirin-sensitive.
Last reviewed on RxList: 1/23/2015
This monograph has been modified to include the generic and brand name in many instances.
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