In this Article

• What is zolmitriptan (Zomig Nasal Spray)?
• What are the possible side effects of nasal zolmitriptan (Zomig Nasal Spray)?
• What is the most important information I should know about nasal zolmitriptan nasal (Zomig Nasal Spray)?
• What should I discuss with my healthcare provider before using nasal zolmitriptan (Zomig Nasal Spray)?
• How should I use nasal zolmitriptan (Zomig Nasal Spray)?
• What happens if I miss a dose (Zomig Nasal Spray)?
• What happens if I overdose (Zomig Nasal Spray)?
• What should I avoid while using nasal zolmitriptan (Zomig Nasal Spray)?
• What other drugs will affect nasal zolmitriptan (Zomig Nasal Spray)?
• Where can I get more information?

What should I discuss with my healthcare provider before using nasal zolmitriptan (Zomig Nasal Spray)?

You should not use this medication if you are allergic to zolmitriptan, or if you have:

• coronary heart disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart;
• a history of heart disease, heart attack, or stroke, including "mini-stroke";
• severe or uncontrolled high blood pressure;
• ischemic bowel disease; or
• a headache that seems different from your usual migraine headaches.

Do not use zolmitriptan if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days.

To make sure you can safely use zolmitriptan, tell your doctor if you have any of these other conditions:

• liver disease;
• kidney disease;
• coronary heart disease (or risk factors such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).
• high blood pressure, a heart rhythm disorder; or

FDA pregnancy category C. It is not known whether zolmitriptan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether zolmitriptan passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medication to a child younger than 18 years old.

How should I use nasal zolmitriptan (Zomig Nasal Spray)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Overuse of migraine headache medicine can actually make your headaches worse.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Use zolmitriptan as soon as you notice headache symptoms, or after an attack has already begun.

The usual dose of zolmitriptan is a single spray into one nostril. Follow your doctor's instructions.

Blow your nose gently to clear your nostrils before using this medication. Remove the protective cap from the nasal spray device. Hold the device upright and insert the tip into your nostril. Hold your other nostril closed with the tip of your index finger.

Tilt your head back slightly and press the plunger on the nasal spray device. Inhale slowly as you spray the zolmitriptan dose into your nostril. Remove the spray device and breathe gently through your nose for 5 to 10 seconds. Keep your head tilted back, as you may feel some liquid in your nose or in the back of your throat.

There is only one spray in each zolmitriptan spray device. Do not press the plunger on the device until you have inserted the tip into your nostril.

After using the nasal spray: If your headache goes away and comes back, use a second dose two (2) hours after the first. Do not use more than 10 mg of zolmitriptan in 24 hours. If your headache does not completely go away, call your doctor before using a second dose of zolmitriptan.

Contact your doctor if you have more than four headaches in one month (30 days).

If you use zolmitriptan long-term, your doctor may want to check your heart function using an electrocardiograph or ECG (sometimes called an EKG), a machine that measures electrical activity of the heart. This will help your doctor determine if it is still safe for you to use this medication. Visit your doctor regularly.

Store at room temperature away from moisture and heat. Keep the protective cap on the nasal spray until you are ready to use it.

Throw away the single-use nasal spray device after one use.