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Zonegran Patient Information Including Side Effects

Brand Names: Zonegran

Generic Name: zonisamide (Pronunciation: zoe NIS a mide)

What is zonisamide (Zonegran)?

Zonisamide is a sulfa drug with anti-convulsant effects.

Zonisamide is used together with other anti-convulsant medications to treat partial seizures in adults with epilepsy.

Zonisamide may also be used for other purposes not listed in this medication guide.

Zonisamide 100 mg-APO

red/white, imprinted with APO, 100

Zonisamide 100 mg-MYL

dark blue/blue, imprinted with MYLAN 6727

Zonisamide 25 mg-APO

white, imprinted with APO, 25

Zonisamide 25 mg-BAR

white, imprinted with barr 25 mg, 827

Zonisamide 25 mg-MYL

dark blue/blue, imprinted with MYLAN 6725

Zonisamide 50 mg-APO

gray/white, imprinted with APO, 50

Zonisamide 50 mg-MYL

blue/white, imprinted with MYLAN 6726

What are the possible side effects of zonisamide (Zonegran)?

Get emergency medical help if you have any of these signs of an allergic reaction: any form of skin rash; hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • the first sign of any skin rash, no matter how mild;
  • increased or worsening seizures;
  • rapid breathing or feeling short of breath with dry mouth, confusion, dizziness or weakness, numbness or tingling, chest pain;;
  • fast, pounding, or uneven heartbeats;
  • pale skin, easy bruising or bleeding, unusual weakness;
  • fever, chills, body aches, flu symptoms, white patches or sores inside your mouth or on your lips;
  • problems with thinking or speech, trouble concentrating;
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • dizziness or weakness and hot, dry skin without sweating;
  • urinating less than usual or not at all; or
  • sudden back pain, stomach or side pain, pain or bleeding when urinating, bloody or dark urine.

Less serious side effects may include:

  • drowsiness, dizziness, headache, tired feeling;
  • mild loss of appetite, weight loss;
  • loss of balance or coordination;
  • sore throat, cough; or
  • blurred vision, ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Zonegran (zonisamide) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about zonisamide (Zonegran)?

Do not use this medication if you are allergic to zonisamide, or to other sulfa drugs such as sulfamethoxazole (Gantanol), sulfisoxazole (Gantrisin), or sulfamethoxazole-trimethoprim (Bactrim, Septra, Cotrim, and others). A sulfa drug allergic reaction can be fatal.

You may have thoughts about suicide while taking this medication. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Zonisamide can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Do not stop taking zonisamide without first talking to your doctor, even if you feel fine. Stopping zonisamide suddenly may cause you to have seizures. You may need to use less and less before you stop the medication completely.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking zonisamide.

Carry an ID card or wear a medical alert bracelet stating that you are taking zonisamide, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication.

Side Effects Centers

Zonegran - User Reviews

Zonegran User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Zonegran sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Find tips and treatments to control seizures.