May 23, 2017
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Zortress Patient Information including How Should I Take

What should I discuss with my health care provider before taking Zortress (Zortress)?

You should not use this medication if you are allergic to everolimus or sirolimus (Rapamune), or if you have problems digesting lactose or galactose (sugar).

To make sure you can safely take everolimus, tell your doctor if you have any of these other conditions:

  • liver disease;
  • high cholesterol or triglycerides;
  • an active infection;
  • diabetes or high blood sugar;
  • a blood clotting disorder;
  • a breathing disorder, such as asthma or COPD (chronic obstructive pulmonary disease);
  • a personal or family history of skin cancer (melanoma); or
  • if you are pregnant or may become pregnant.

Taking Zortress may increase your risk of developing other types of cancer such as lymphoma or skin cancer. Ask your doctor about your individual risk.

FDA pregnancy category C. It is not known whether Zortress will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Use effective birth control while you are using this medication and for at least 8 weeks after your treatment ends.

Zortress can lower sperm count in men, which may affect fertility (your ability to have children).

It is not known whether everolimus passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking Zortress.

How should I take Zortress (Zortress)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Do not stop taking Zortress or change your dose without first talking to your doctor.

Zortress is usually taken twice daily (every 12 hours). You may take the medicine with or without food, but take it the same way each time. If you also take cyclosporine, take both medications at the same time.

Take this medication with a full glass (8 ounces) of water.

Do not crush or chew an everolimus tablet. Swallow the pill whole.

Everolimus can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood will need to be tested often. Your kidney function will also need to be tested. Visit your doctor regularly.

Store at room temperature in the original container, away from moisture, heat, and light. Keep each tablet in its blister pack until you are ready to take it.

Side Effects Centers

Zortress - User Reviews

Zortress User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Zortress sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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