"Despite wide publicity accorded the 2014 to 2015 national outbreak of measles, linked to Disneyland in Orange County, California, many US parents remained unaware of the spate of cases, according to survey results from parents of children aged 5 "...
There have been postmarketing reports of overdose with piperacillin/tazobactam. The majority of those events experienced, including nausea, vomiting, and diarrhea, have also been reported with the usual recommended dosages. Patients may experience neuromuscular excitability or convulsions if higher than recommended doses are given intravenously (particularly in the presence of renal failure) [see WARNINGS AND PRECAUTIONS].
Treatment should be supportive and symptomatic according the patient's clinical presentation. Excessive serum concentrations of either piperacillin or tazobactam may be reduced by hemodialysis. Following a single 3.375 g dose of piperacillin/tazobactam, the percentage of the piperacillin and tazobactam dose removed by hemodialysis was approximately 31% and 39%, respectively [see CLINICAL PHARMACOLOGY].
ZOSYN is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or β-lactamase inhibitors.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 9/19/2013
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