July 30, 2016
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Zovirax

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Zovirax




Side Effects
Interactions

SIDE EFFECTS

Adverse Drug Reaction Overview

The most frequent adverse reactions associated with the use of ZOVIRAX® (acyclovir) are headache and nausea.

Neurological side effects have also been reported in rare instances. Elderly patients and patients with a history of renal impairment are at increased risk of developing these effects. In the reported cases, these reactions were generally reversible on discontinuation of treatment (see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS, Post-Market Adverse Drug Reactions).

Clinical Trial Adverse Drug Reactions

Because clinical trials are conducted under very specific conditions the adverse reaction rates observed in the clinical trials may not reflect the rates observed in practice and should not be compared to the rates in the clinical trials of another drug. Adverse drug reaction information from clinical trials is useful for identifying drug-related adverse events and for approximating rates.

Treatment of Herpes Simplex

Short-term administration (5-10 days): The most frequent adverse reactions reported during clinical trials of treatment of genital herpes with oral ZOVIRAX® in 298 patients are listed in Table 1.

Table 1 : Adverse Reactions Reported in Clinical Trials of Treatment of Genital Herpes with Acyclovir

Adverse Reactions Total %
Nausea and/or Vomiting 8 2.7

Suppression of Herpes Simplex

Long-term administration: The most frequent adverse events reported in a clinical trial for the prevention of recurrences with continuous administration of 400 mg (two 200 mg capsules) 2 times daily are listed in Table 2.

Table 2 : Adverse Reactions Reported in a Clinical Trial for the Prevention of Recurrences of Genital Herpes with Acyclovir

Adverse Reactions 1st Year
(n=586) %
2nd Year
(n=390) %
3rd Year
(n=329) %
Nausea 4.8    
Diarrhea 2.4    
Headache 1.9 1.5 0.9
Rash 1.7 1.3  
Paresthesia   0.8 1.2
Asthenia     1.2

Evidence so far from clinical trials suggests that the severity and frequency of adverse events is unlikely to necessitate discontinuation of therapy.

Herpes Zoster

The most frequent adverse reactions reported during three clinical trials of treatment of herpes zoster (shingles) with 800 mg of oral ZOVIRAX® 5 times daily for 7 or 10 days or placebo are listed in Table 3.

Table 3 : Adverse Reactions Reported in Clinical Trials of Treatment of Herpes Zoster

Adverse Reactions ZOVIRAX®
(n=323) %
Placebo
(n=323) %
Malaise 11.5 11.1
Nausea 8.0 11.5
Headache 5.9 11.1
Vomiting 2.5 2.5
Diarrhea 1.5 0.3

Chickenpox

The most frequent adverse events reported during three clinical trials of treatment of chickenpox with oral ZOVIRAX® or placebo are listed in Table 4.

Table 4 : Adverse Reactions Reported in Clinical Trials of Treatment of Chickenpox

Adverse Reactions ZOVIRAX®
(n=495)%
Placebo
(n=498)%
Diarrhea 3.2 2.2

Less Common Clinical Trial Adverse Drug Reactions ( < 1%)

Other adverse reactions reported in less than 1% of patients receiving ZOVIRAX® in any clinical trial included: abdominal pain, anorexia, constipation, dizziness, edema, fatigue, flatulence, inguinal adenopathy, insomnia, leg pain, medication taste, skin rash, sore throat, spasmodic hand movement and urticaria.

Abnormal Hematologic And Clinical Chemistry Findings

No clinically significant changes in laboratory values have been observed in clinical trials for the treatment of chickenpox and zoster, and for the treatment and suppression of genital herpes with ZOVIRAX®.

Post-Market Adverse Drug Reactions

The following events have been reported voluntarily during post-market use of ZOVIRAX® in clinical practice. These events have been chosen for inclusion due to either their seriousness, frequency of reporting, potential causal connection to ZOVIRAX® or a combination of these factors. Post-market adverse events are reported spontaneously from a population of unknown size, thus estimates of frequency cannot be made.

General: Fever, headache, pain and peripheral edema.

Nervous: Dizziness, paresthesia, agitation, confusion, tremor, ataxia, dysarthria, hallucinations, psychotic symptoms, convulsions, somnolence, encephalopathy and coma have been reported. These events are generally reversible and usually reported in patients with renal impairment, or with other predisposing factors (see WARNINGS AND PRECAUTIONS). These symptoms may be marked, particularly in older adults.

Digestive: Diarrhea, gastrointestinal distress and nausea.

Hematogical and Lymphatic: Anaemia, leukopenia, lymphadenopathy and thrombocytopenia.

Hypersensitivity and Skin: Alopecia, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, rashes including photosensitivity, pruritus, urticaria, dyspnoea, angioedema and anaphylaxis.

Hepatobiliary Tract and Pancreas: Reports of reversible hyperbilirubinemia and elevated liver related enzymes. Hepatitis and jaundice.

Musculoskeletal: Myalgia.

Special Senses: Visual abnormalities.

Urogenital: Elevated blood creatinine and blood urea nitrogen (BUN). Acute renal failure, renal pain and hematuria have been reported. Renal pain may be associated with renal failure (see WARNINGS AND PRECAUTIONS).

Read the Zovirax (acyclovir) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

Drug-Drug Interactions

No clinically significant interactions have been identified.

Acyclovir is eliminated primarily unchanged in the urine via active renal tubular secretion. Any drugs administered concurrently that compete with this mechanism may increase acyclovir plasma concentrations. Probenecid and cimetidine increase the area under the curve (AUC) of acyclovir by this mechanism, and reduce acyclovir renal clearance. Similarly, increases in plasma AUCs of acyclovir and of the inactive metabolite of mycophenolate mofetil, an immunosuppressant agent used in transplant patients have been shown when the drugs are coadministered. However, no dosage adjustment is necessary because of the wide therapeutic index of acyclovir.

Drug-Food Interactions

There is no known interaction with food (see Action And Clinical Pharmacology, Pharmacokinetics).

Drug-Herb Interactions

Interactions with herbal products have not been established.

Drug-Laboratory Test Interactions

Interactions with laboratory tests have not been established.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 1/7/2016

Side Effects
Interactions

Zovirax - User Reviews

Zovirax User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Zovirax sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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