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Zovirax Injection Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Zovirax (acyclovir sodium) for Injection is an antiviral that is used for treating infections caused by the herpes virus. Common side effects include nausea, vomiting, diarrhea, loss of appetite, or headache.
Zovirax is given as an IV injection as directed by your doctor. It is usually given for at least once every 8 hours for 5 to 10 days. Zovirax may interact with tizanidine, probenecid, or drugs affecting the kidneys (e.g., amphotericin B, cisplatin, and aminoglycosides such as gentamicin). Tell your doctor all medications you use. Zovirax will not prevent the spread of genital herpes. Avoid sexual intercourse or use a latex condom to prevent spreading the virus to others. Zovirax should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Zovirax is excreted in breast milk. Consult your doctor before breastfeeding.
Our Zovirax (acyclovir sodium) for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Zovirax Injection in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using acyclovir and call your doctor at once if you have a serious side effect such as:
- urinating less than usual or not at all;
- fever, chills, body aches, flu symptoms;
- a red, blistering, peeling skin rash;
- jaundice (yellowing of the skin or eyes);
- swelling, pain, tenderness, or skin changes where the injection was given;
- pale skin, easy bruising or bleeding, weakness; or
- confusion, tremors, agitation, tiredness, hallucinations, or seizure (convulsions).
Less serious side effects may include:
- nausea, vomiting, diarrhea, stomach pain, loss of appetite;
- muscle pain, numbness or tingling;
- loss of coordination;
- headache, feeling light-headed; or
- swelling in your hands or feet.
Read the entire detailed patient monograph for Zovirax Injection (Acyclovir for Injection)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Zovirax Injection Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: pain/swelling at the injection site, shaking, dizziness, drowsiness, unusual tiredness, fast/pounding heartbeat, easy bruising/bleeding, new signs of infection (e.g., fever, persistent sore throat), bloody/dark urine, severe stomach/abdominal pain, yellowing eyes/skin, change in the amount of urine, mental/mood changes (e.g., agitation, confusion, hallucinations), loss of consciousness, vision changes, seizures.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Zovirax Injection (Acyclovir for Injection)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Zovirax Injection FDA Prescribing Information: Side Effects
The adverse reactions listed below have been observed in controlled and uncontrolled clinical trials in approximately 700 patients who received ZOVIRAX at ~5 mg/kg (250 mg/m²) 3 times daily, and approximately 300 patients who received ~10 mg/kg (500 mg/m²) 3 times daily.
The most frequent adverse reactions reported during administration of ZOVIRAX were inflammation or phlebitis at the injection site in approximately 9% of the patients, and transient elevations of serum creatinine or BUN in 5% to 10% (the higher incidence occurred usually following rapid [less than 10 minutes] intravenous infusion). Nausea and/or vomiting occurred in approximately 7% of the patients (the majority occurring in nonhospitalized patients who received 10 mg/kg). Itching, rash, or hives occurred in approximately 2% of patients. Elevation of transaminases occurred in 1% to 2% of patients.
The following hematologic abnormalities occurred at a frequency of less than 1%: anemia, neutropenia, thrombocytopenia, thrombocytosis, leukocytosis, and neutrophilia. In addition, anorexia and hematuria were observed.
Observed During Clinical Practice
In addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of ZOVIRAX for Injection in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These events have been chosen for inclusion due to either their seriousness, frequency of reporting, potential causal connection to ZOVIRAX, or a combination of these factors.
Hematologic and Lymphatic
Hepatobiliary Tract and Pancreas
Aggressive behavior, agitation, ataxia, coma, confusion, delirium, dizziness, dysarthria, encephalopathy, hallucinations, obtundation, paresthesia, psychosis, seizure, somnolence, tremor. These symptoms may be marked, particularly in older adults (see PRECAUTIONS).
Alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria. Severe local inflammatory reactions, including tissue necrosis, have occurred following infusion of ZOVIRAX into extravascular tissues.
Read the entire FDA prescribing information for Zovirax Injection (Acyclovir for Injection)
Additional Zovirax Injection Information
Zovirax Injection - User Reviews
Zovirax Injection User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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