Chickenpox is a common childhood skin disease caused by a viral infection. The virus involved is called the varicella-zoster virus. Today, chickenpox is less common in the United States due to universal vaccination with the varicella virus vaccine, though it still occurs in populations that are not routinely vaccinated. Varicella-zoster virus is often categorized with the other common so-called "viral exanthems" (viral rashes) such as measles (rubeola), German measles (rubella), fifth disease (parvovirus B19), mumps virus, and roseola (human herpesvirus 6), but these viruses are unrelated except for their tendency to cause rashes.
In unimmunized populations, most people contract chickenpox by age 15, the majority between ages 5 and 9, but all ages can contract it. Chickenpox is usually more severe in adults and very young infants than children. Winter and spring are the most common times of the year for chicke...
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In the controlled clinical trials, mild pain (including transient burning and stinging) was reported by about 30% of patients in both the active and placebo arms; treatment was discontinued in 2 of these patients. Local pruritus occurred in 4% of these patients. In all studies, there was no significant difference between the drug and placebo group in the rate or type of reported adverse reactions nor were there any differences in abnormal clinical laboratory findings.
Observed During Clinical Practice: Based on clinical practice experience in patients treated with ZOVIRAX Ointment (acyclovir ointment) in the US, spontaneously reported adverse events are uncommon. Data are insufficient to support an estimate of their incidence or to establish causation. These events may also occur as part of the underlying disease process. Voluntary reports of adverse events that have been received since market introduction include:
General: Edema and/or pain at the application site.
Skin: Pruritus, rash.
Clinical experience has identified no interactions resulting from topical or systemic administration of other drugs concomitantly with ZOVIRAX Ointment (acyclovir ointment) 5%.
Last reviewed on RxList: 8/13/2008
This monograph has been modified to include the generic and brand name in many instances.
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