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Zutripro

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Zutripro

ZUTRIPRO
(hydrocodone bitartrate, chlorpheniramine maleate, and pseudoephedrine hydrochloride) Oral Solution

DRUG DESCRIPTION

ZUTRIPRO Oral Solution contains hydrocodone bitartrate (a semisynthetic centrally-acting opioid antitussive), Chlorpheniramine maleate (an antihistamine), and pseudoephedrine hydrochloride (an indirect sympathomimetic amine).

Each 5 mL dose of ZUTRIPRO Oral Solution contains: hydrocodone bitartrate, USP, 5 mg; Chlorpheniramine maleate, USP, 4 mg; and pseudoephedrine hydrochloride, USP, 60 mg.

ZUTRIPRO Oral Solution also contains: citric acid anhydrous, glycerin, grape flavor, methylparaben, propylene glycol, propylparaben, purified water, sodium citrate, sodium saccharin, and sucrose.

Hydrocodone bitartrate is morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5α)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1), hydrate (2:5); also known as 4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5); a fine white crystal or crystalline powder, which is derived from the opium alkaloid, thebaine; and may be represented by the following structural formula:

Hydrocodone bitartrate Structural Formula Illustration

Hydrocodone Bitartrate
C18H21N03•C4H606•2.5 H20
Molecular weight = 494.5

Chlorpheniramine maleate is 2-pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1) and has the following chemical structure:

Chlorpheniramine maleate Structural Formula Illustration
Chlorpheniramine Maleate
C16H19C1N2•C4H404
Molecular weight = 390.86

Pseudoephedrine hydrochloride is benzenemethanol, α-[l-(methylamino)ethyl]-, [S-(R*,R*)] hydrochloride and has the following chemical structure:

Pseudoephedrine hydrochloride Structural Formula Illustration

Pseudoephedrine Hydrochloride
C10H15NO•HC1
Molecular weight = 201.69

Last reviewed on RxList: 6/30/2011
This monograph has been modified to include the generic and brand name in many instances.

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