February 14, 2016
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"Common colds are the main reason that children miss school and adults miss work. Each year in the United States, there are millions of cases of the common cold. Adults have an average of 2-3 colds per year, and children have even more.




(hydrocodone bitartrate, chlorpheniramine maleate, and pseudoephedrine hydrochloride) Oral Solution


ZUTRIPRO Oral Solution contains hydrocodone bitartrate (a semisynthetic centrally-acting opioid antitussive), Chlorpheniramine maleate (an antihistamine), and pseudoephedrine hydrochloride (an indirect sympathomimetic amine).

Each 5 mL dose of ZUTRIPRO Oral Solution contains: hydrocodone bitartrate, USP, 5 mg; Chlorpheniramine maleate, USP, 4 mg; and pseudoephedrine hydrochloride, USP, 60 mg.

ZUTRIPRO Oral Solution also contains: citric acid anhydrous, glycerin, grape flavor, methylparaben, propylene glycol, propylparaben, purified water, sodium citrate, sodium saccharin, and sucrose.

Hydrocodone bitartrate is morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5α)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1), hydrate (2:5); also known as 4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5); a fine white crystal or crystalline powder, which is derived from the opium alkaloid, thebaine; and may be represented by the following structural formula:

Hydrocodone bitartrate Structural Formula Illustration

Hydrocodone Bitartrate
C18H21N03•C4H606•2.5 H20
Molecular weight = 494.5

Chlorpheniramine maleate is 2-pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1) and has the following chemical structure:

Chlorpheniramine maleate Structural Formula Illustration
Chlorpheniramine Maleate
Molecular weight = 390.86

Pseudoephedrine hydrochloride is benzenemethanol, α-[l-(methylamino)ethyl]-, [S-(R*,R*)] hydrochloride and has the following chemical structure:

Pseudoephedrine hydrochloride Structural Formula Illustration

Pseudoephedrine Hydrochloride
Molecular weight = 201.69

Last reviewed on RxList: 6/30/2011
This monograph has been modified to include the generic and brand name in many instances.

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