Brand Names: Aplenzin, Budeprion SR, Budeprion XL, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack

Generic Name: bupropion (oral) (Pronunciation: byoo PRO pee on)

• What is bupropion (Zyban)?
• What are the possible side effects of bupropion?
• What is the most important information I should know about bupropion?
• What should I discuss with my healthcare provider before taking bupropion?
• How should I take bupropion?
• What happens if I miss a dose?
• What happens if I overdose?
• What should I avoid while taking bupropion?
• What other drugs will affect bupropion?
• Where can I get more information?

What is bupropion (Zyban)?

Bupropion is an antidepressant medication.

Bupropion is used to treat major depressive disorder and seasonal affective disorder. At least one brand of bupropion (Zyban) is used to help people stop smoking by reducing cravings and other withdrawal effects.

Bupropion may also be used for purposes other than those listed in this medication guide.

Budeprion 150 mg

round, yellow, imprinted with 2444, G

Budeprion XL 150 mg-TEV

round, white, imprinted with A 101

Budeprion XL 300 mg-TEV

oval, yellow, imprinted with 682, G

Bupropion 100 mg-APO

round, purple, imprinted with APO, BUP 100

BuPROPion 100 mg-GG

round, lavender, imprinted with GG 930

Bupropion 100 mg-MYL

round, blue, imprinted with M, 435

Bupropion 200 mg XL-EON

round, pink, imprinted with 1111, E

Bupropion 75 mg-APO

round, orange, imprinted with APO, BU 75

BuPROPion 75 mg-GG

round, lavender, imprinted with GG 929

Bupropion 75 mg-MYL

round, peach, imprinted with M, 433

Bupropion ER 200 mg-GLO

round, orange, imprinted with 555

Bupropion HCl SR 100 mg-WAT

round, white, imprinted with WPI 858

Bupropion HCl SR 150 mg-WAT

round, white, imprinted with WPI 839

Bupropion HCl SR 200 mg-WAT

round, white, imprinted with WPI 3385

Bupropion SR 100 mg-TEV

round, yellow, imprinted with G, 2442

Bupropion SR 150 mg-TEV

round, yellow, imprinted with G, 2444

Bupropion XL 300 mg-WAT

round, white, imprinted with WPI 3332

Buproprion 100 mg-TEV

round, pink, imprinted with 93 290

Buproprion 75 mg-TEV

round, yellow, imprinted with 93 280

Buproprion XL 150 mg-EON

round, purple, imprinted with E 415

Wellbutrin 100 mg

round, red, imprinted with WELLBUTRIN 100

Wellbutrin 75 mg

round, yellow, imprinted with WELLBUTRIN 75

Wellbutrin SR 100 mg

round, blue, imprinted with WELLBUTRIN SR 100

Wellbutrin SR 150 mg

round, lavender, imprinted with WELLBUTRIN SR 100

Wellbutrin SR 200 mg

round, pink, imprinted with WELLBUTRIN SR 200

Wellbutrin XL 150 mg

round, beige, imprinted with WELLBUTRIN XL 150

Wellbutrin XL 300 mg

round, white, imprinted with WELLBUTRIN XL 300

Zyban 150 mg

round, lavender, imprinted with ZYBAN 150

What are the possible side effects of bupropion?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

• seizure (convulsions);
• severe blistering, peeling, and red skin rash;
• fever, swollen glands, rash or itching, joint pain, or general ill feeling;
• confusion, trouble concentrating; or
• hallucinations, unusual thoughts or behavior.

Less serious side effects may include:

• headache or migraine;
• sleep problems (insomnia);
• nausea, vomiting, constipation, dry mouth;
• dizziness, tremors (shaking);
• appetite changes, weight loss or gain;
• mild itching or skin rash, increased sweating; or
• loss of interest in sex.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about bupropion?

Do not take bupropion if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl), or tranylcypromine (Parnate) in the last 14 days.

You should not take bupropion if you have seizures, an eating disorder, if you are using a second form of bupropion, or if you have suddenly stopped using alcohol or sedatives.

Bupropion may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not smoke at any time if you are using a nicotine product along with Zyban. Too much nicotine can cause serious side effects.

Avoid drinking alcohol while taking bupropion. Alcohol may increase your risk of a seizure while you are taking bupropion.