Zyclara (Imiquimod Cream) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

Zyclara

Actinic Keratosis »

What is an actinic keratosis, and what does it look like?

An actinic keratosis (AK), also known as a solar keratosis, is a small, rough spot occurring on skin that has been chronically exposed to the sun. Actinic keratoses generally measure in size between 2-6 millimeters in diameter (between the size of a pencil point and that of an eraser). They are usually reddish in color, with a rough texture and often have a white or yellowish scale on top. Actinic keratosis often occurs against a background of sun damage, including sallowness, wrinkles, and superficial blood vessels.

In addition to feeling rough, actinic keratoses may feel sore or painful when fingers or clothing rub against them.

Specialized forms of actinic keratoses include cutaneous horns, in which the skin protrudes in a thick, hornlike manner, and actinic cheilitis, which refers to scaling and roughness of the lower lip and blurring of the border of the lip and adjacent ski...

Read the Actinic Keratosis article »

Zyclara

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ZYCLARA
(imiquimod) Cream, 3.75%, for Topical Use

ZYCLARA
(imiquimod) Cream, 2.5%, for Topical Use

DRUG DESCRIPTION

ZYCLARA (imiquimod) Cream, 2.5% or 3.75% is intended for topical administration. Each gram contains 25 mg or 37.5 mg of imiquimod, respectively, in a white to faintly yellow oil-in-water cream base consisting of isostearic acid, cetyl alcohol, stearyl alcohol, white petrolatum, polysorbate 60, sorbitan monostearate, glycerin, xanthan gum, purified water, benzyl alcohol, methylparaben, and propylparaben.

Chemically, imiquimod is l-(2-methylpropyl)-lH-imidazol[4,5-c]quinolin-4-amine.

Imiquimod has a molecular formula of C₁₄H₁₆N₄ and a molecular weight of 240.3. Its structural formula is:

ZYCLARA
(imiqulmod) Structural Formula Illustration

ZYCLARA (imiquimod) Cream, 2.5% and 3.75% come as premeasured packets containing 6.25 mg and 9.4 mg of imiquimod, respectively, in 0.25 g of cream. ZYCLARA (imiquimod) Cream, 2.5% and 3.75% also come in pumps which dispense 5.9 mg or 8.8 mg of imiquimod, respectively, in 0.235 g of cream per full actuation of the pump after priming.

Last reviewed on RxList: 3/1/2012
This monograph has been modified to include the generic and brand name in many instances.