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Gout is a disease that results from an overload of uric acid in the body. This overload of uric acid leads to the formation of tiny crystals of urate that deposit in tissues of the body, especially the joints. When crystals form in the joints, it causes recurring attacks of joint inflammation (arthritis). Gout is considered a chronic and progressive disease. Chronic gout can also lead to deposits of hard lumps of uric acid in the tissues, particularly in and around the joints and may cause joint destruction, decreased kidney function, and kidney stones (nephrolithiasis).
Gout has the unique distinction of being one of the most frequently recorded medical illnesses throughout history. It is often related to an inherited abnormality in the body's ability to process uric acid. Uric acid is a breakdown product of purines that are part of many foods we eat. An abnormality in handling uric acid can cause attacks of p...
Medical Editor: Charles Patrick Davis, MD, PhD
Zyloprim (allopurinol) is a xanthine oxidase inhibitor that reduces the production of uric acid. Zyloprim is used to prevent gout attacks by reducing uric acid production; high levels of uric acid may cause gout or kidney stones. Zyloprim is available as a generic termed allopurinol. Side effects of Zyloprim may include drowsiness, diarrhea, and stomach discomfort.
Zyloprim is available in 100 and 300 mg strength tablets. The usual doses start at 200 - 300 mg per day; dosage for children with hyperuricemia under 6 years old is 150 mg per day. Zyloprim is usually recommended to be taken after a meal. Some serious side effects of Zyloprim may include swelling of mouth and lips, severe skin rashes, infections, eye irritation, hepatitis, appetite and weight loss, and painful or bloody urination. Zyloprim should be used during pregnancy only if clearly needed and used with caution in women who are breastfeeding; benefits vs. harm to the fetus or infant should be considered. Zyloprim has been used in certain pediatric patient populations with hyperuricemia.
Our Zyloprim Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases, and conditions.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
THIS IS NOT AN INNOCUOUS DRUG. IT IS NOT RECOMMENDED FOR THE TREATMENT OF ASYMPTOMATIC HYPERURICEMIA.
ZYLOPRIM (allopurinol) reduces serum and urinary uric acid concentrations. Its use should be individualized for each patient and requires an understanding of its mode of action and pharma-cokinetics (see CLINICAL PHARMACOLOGY, CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS). ZYLOPRIM (allopurinol) is indicated in:
Read the complete drug monograph for Zyloprim »
Drug Description - Indications & Dosage - Side Effects & Drug Interactions - Warnings & Precautions - Contraindications - Medication Guide and More
What is Patient information?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using allopurinol and call your doctor at once if you have any of these serious side effects:
Read the complete patient information for Zyloprim »
Possible Side Effects - Images - What Is - How Should I Take It - What If I Miss a Dose - What Should I Avoid and More
What is Consumer information?
A concise overview of the drug for the patient or caregiver from First DataBank.
HOW TO USE: Take this medication by mouth, usually once daily or as directed by your doctor. Take this medication after a meal to reduce stomach ...
Read the complete consumer information for Zyloprim »
Warnings - Uses - How to Use - Side Effects - Precautions - Drug Interactions and More
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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