"The U.S. Food and Drug Administration today approved Krystexxa (pegloticase) to treat the painful condition known as gout in adults who do not respond to or who cannot tolerate conventional therapy.
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(allopurinol) 100-mg Scored Tablets and 300-mg Scored Tablets
- Patient Information:
Details with Side Effects
ZYLOPRIM (allopurinol) has the following structural formula:
ZYLOPRIM (allopurinol) is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg allopurinol and the inactive ingredients lactose, magnesium stearate, potato starch, and povidone. Each scored peach tablet contains 300 mg allopurinol and the inactive ingredients corn starch, FD&C Yellow No. 6 Lake, lactose, magnesium stearate, and povidone. Its solubility in water at 37°C is 80.0 mg/dL and is greater in an alkaline solution.
What are the possible side effects of allopurinol (Zyloprim)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using allopurinol and call your doctor at once if you have a serious side effect such as:
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
- the first sign of any skin rash, no matter how mild;
- pain or bleeding when you urinate;
- nausea, upper stomach pain, itching, loss of appetite, weight loss, dark urine, clay-colored stools, jaundice...
What are the precautions when taking allopurinol (Zyloprim)?
Before taking allopurinol, tell your doctor or pharmacist if you are allergic to it; or if you have had a severe reaction to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, diabetes, high blood pressure (hypertension), unusual diets (e.g., fasting).
This drug may make you drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.
Alcohol may decrease the effectiveness of this drug. Limit alcoholic beverages.
Last reviewed on RxList: 10/11/2010
This monograph has been modified to include the generic and brand name in many instances.
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