"The U.S. Food and Drug Administration today approved Krystexxa (pegloticase) to treat the painful condition known as gout in adults who do not respond to or who cannot tolerate conventional therapy.
Gout occurs due to an excess of the b"...
Patients should be informed of the following:
(1) They should be cautioned to discontinue ZYLOPRIM (allopurinol) and to consult their physician immediately at the first sign of a skin "rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips or mouth. (2) They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of ZYLOPRIM (allopurinol) may be delayed for 2 to 6 weeks. (3) They should be encouraged to increase fluid intake during therapy to prevent renal stones. (4) If a single dose of ZYLOPRIM (allopurinol) is occasionally forgotten, there is no need to double the dose at the next scheduled time. (5) There may be certain risks associated with the concomitant use of ZYLOPRIM (allopurinol) and dicumarol, sulfinpyrazone, mercap-topurine, azathioprine, ampicillin, amoxicillin, and thiazide diuretics, and they should follow the instructions of their physician. (6) Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in activities where alertness is mandatory. (7) Patients may wish to take ZYLOPRIM (allopurinol) after meals to minimize gastric irritation.
Last reviewed on RxList: 10/11/2010
This monograph has been modified to include the generic and brand name in many instances.
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