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home > drugs a-z list > zyloprim (allopurinol) drug center > zyloprim (allopurinol) drug - overdosage and contraindications
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Zyloprim
What is gout? What is hyperuricemia?
Gout is a disease that results from an overload of uric acid in the body. This overload of uric acid leads to the formation of tiny crystals of urate that deposit in tissues of the body, especially the joints. When crystals form in the joints, it causes recurring attacks of joint inflammation (arthritis). Gout is considered a chronic and progressive disease. Chronic gout can also lead to deposits of hard lumps of uric acid in the tissues, particularly in and around the joints and may cause joint destruction, decreased kidney function, and kidney stones (nephrolithiasis).
Gout has the unique distinction of being one of the most frequently recorded medical illnesses throughout history. It is often related to an inherited abnormality in the body's ability to process uric acid. Uric acid is a breakdown product of purines that are part of many foods we eat. An abnormality in handling uric acid can cause attacks of p...
Zyloprim
OVERDOSE
Massive overdosing or acute poisoning by ZYLOPRIM (allopurinol) has not been reported.
In mice, the 50% lethal dose (LD50) is 160 mg/kg given intraperitoneally (IP) with deaths delayed up to 5 days and 700 mg/kg orally (PO) (approximately 140 times the usual human dose) with deaths delayed up to 3 days. In rats, the acute LD50 is 750 mg/kg IP and 6000 mg/kg PO (approximately 1200 times the human dose).
In the management of overdosage there is no specific antidote for ZYLOPRIM (allopurinol) . There has been no clinical experience in the management of a patient who has taken massive amounts of ZYLOPRIM (allopurinol) .
Both ZYLOPRIM (allopurinol) and oxipurinol are dialyzable; however, the usefulness of hemodialysis or peritoneal dialysis in the management of an overdose of ZYLOPRIM (allopurinol) is unknown.
CONTRAINDICATIONS
Patients who have developed a severe reaction to ZYLOPRIM (allopurinol) should not be restarted on the drug.
Last reviewed on RxList: 10/11/2010
This monograph has been modified to include the generic and brand name in many instances.
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