"The U.S. Food and Drug Administration today approved Krystexxa (pegloticase) to treat the painful condition known as gout in adults who do not respond to or who cannot tolerate conventional therapy.
Gout occurs due to an excess of the b"...
In mice, the 50% lethal dose (LD50) is 160 mg/kg given intraperitoneally (IP) with deaths delayed up to 5 days and 700 mg/kg orally (PO) (approximately 140 times the usual human dose) with deaths delayed up to 3 days. In rats, the acute LD50 is 750 mg/kg IP and 6000 mg/kg PO (approximately 1200 times the human dose).
In the management of overdosage there is no specific antidote for ZYLOPRIM (allopurinol) . There has been no clinical experience in the management of a patient who has taken massive amounts of ZYLOPRIM (allopurinol) .
Patients who have developed a severe reaction to ZYLOPRIM (allopurinol) should not be restarted on the drug.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 10/11/2010
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