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Zyprexa Relprevv

Last reviewed on RxList: 3/21/2017
Zyprexa Relprevv Patient Information Including Side Effects

Brand Names: Zyprexa, ZyPREXA Relprevv

Generic Name: olanzapine (injection) (Pronunciation: oh LAN za peen)

What is olanzapine injection (Zyprexa Relprevv)?

Olanzapine is an antipsychotic medication that affects chemicals in the brain.

Olanzapine injection is used to treat adults who are in an agitated state due to schizophrenia or bipolar disorder (manic depression). Olanzapine injection is not for daily use to treat any psychotic condition.

Olanzapine injection may also be used for purposes not listed in this medication guide.

What are the possible side effects of olanzapine injection (Zyprexa Relprevv)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • fast or slow heart rate;
  • feeling like you might pass out;
  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; or
  • being unable to sit still.

Less serious side effects may include:

  • dizziness, drowsiness;
  • weakness;
  • tremors or shaking;
  • nausea; or
  • pain where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Zyprexa Relprevv (olanzapine extended release injectable suspension) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about olanzapine injection (Zyprexa Relprevv)?

You should not receive this medication if you are allergic to olanzapine.

If possible before you receive olanzapine injection, tell your doctor if you have heart disease, congestive heart failure, a heart rhythm disorder, a history of heart attack or stroke, or if you are also using a sedative such as Valium.

You may need to stop breast-feeding for a short time after receiving an olanzapine injection. Follow your doctor's instructions.

In an emergency situation it may not be possible before you are treated to tell your caregivers about your health conditions or if you are pregnant or breast feeding. Make sure any doctor caring for you afterward knows that you have received this medicine.

Olanzapine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Zyprexa Relprevv Patient Information including How Should I Take

What should I discuss with my healthcare provider before receiving olanzapine injection (Zyprexa Relprevv)?

Olanzapine is not for use in psychotic conditions related to dementia. Olanzapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

You should not receive this medication if you are allergic to olanzapine.

If possible before you receive olanzapine injection, tell your doctor if you have:

  • heart disease;
  • congestive heart failure;
  • a heart rhythm disorder;
  • a history of heart attack or stroke; or
  • if you are also using a sedative such as Valium.

FDA pregnancy category C. It is not known whether olanzapine injection will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Olanzapine can pass into breast milk and may harm a nursing baby. You may need to stop breast-feeding for a short time after receiving an olanzapine injection. Follow your doctor's instructions.

In an emergency situation, it may not be possible before you are treated with olanzapine to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.

How is olanzapine injection given (Zyprexa Relprevv)?

Olanzapine is injected into a muscle. You will receive this injection in a clinic or hospital setting.

An olanzapine injection is usually given only once. If you still have symptoms after 2 hours, your caregivers may use a second or third dose.

Zyprexa Relprevv Patient Information including If I Miss a Dose

What happens if I miss a dose (Zyprexa Relprevv)?

Since olanzapine injection is given by a healthcare professional in an emergency setting, you are not likely to miss a dose.

What happens if I overdose (Zyprexa Relprevv)?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving olanzapine injection (Zyprexa Relprevv)?

Olanzapine may impair your thinking or reactions. Be careful if you do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can increase sleepiness caused by olanzapine.

What other drugs will affect olanzapine injection (Zyprexa Relprevv)?

Tell your doctor about all other medicines you use, especially:

  • blood pressure medication;
  • alprazolam (Xanax)
  • diazepam (Valium);
  • clonazepam (Klonopin);
  • lorazepam (Ativan);
  • temazepam (Restoril); or
  • if you take olanzapine by mouth (Zyprexa, Symbyax, or Zyprexa Zydis).

This list is not complete and other drugs may interact with olanzapine injection. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about olanzapine injection.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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