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(cetirizine HCl 5 mg/pseudoephedrine HCl 120 mg) Tablets
ZYRTEC-D® (cetirizine, pseudoephedrine) Tablets (cetirizine hydrochloride 5 mg and pseudoephedrine hydrochloride 120 mg) Extended Release Tablets for oral administration contain 5 mg of cetirizine hydrochloride for immediate release and 120 mg of pseudoephedrine hydrochloride for extended release in a bilayer tablet. Tablets also contain as inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose.
Cetirizine hydrochloride, one of the two active components of ZYRTEC-D (cetirizine, pseudoephedrine) Tablets, is an orally active and selective H1-receptor antagonist. The chemical name is (+/-)- [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy] acetic acid, dihydrochloride. Cetirizine hydrochloride is a racemic compound with an empirical formula of C21H25ClN2O3•2HCl. The molecular weight is 461.82. Cetirizine hydrochloride is a white, crystalline powder and is water-soluble.
Pseudoephedrine hydrochloride, the other active ingredient of ZYRTEC-D (cetirizine, pseudoephedrine) Tablets, is an adrenergic (vasoconstrictor) agent with the chemical name (1S.2S)-2-methylamino-1-phenyl-1-propanol hydrochloride. The molecular weight is 201.70. The molecular formula is C10H15NO•HCl. Pseudoephedrine hydrochloride occurs as fine, white to off-white crystals or powder, having a faint characteristic odor. It is very soluble in water, freely soluble in alcohol, and sparingly soluble in chloroform.
|Active ingredient (in each extended release tablet)||Purpose|
|Cetirizine HCl 5 mg||Antihistamine|
|Pseudoephedrine HCl 120 mg mg||Nasal decongestant|
colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide
What are the possible side effects of cetirizine and pseudoephedrine (All Day Allergy-D, Zyrtec-D)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:
- fast, pounding, or uneven heartbeat;
- weakness, tremors (uncontrolled shaking), or sleep problems (insomnia);
- severe restless feeling, hyperactivity;
- extreme feeling of fear or confusion;
- increased blood pressure (severe headache, blurred...
What are the precautions when taking cetirizine, pseudoephedrine (Zyrtec-D)?
Before taking this medication, tell your doctor or pharmacist if you are allergic to cetirizine or pseudoephedrine; or to hydroxyzine; or to levocetirizine; or if you have any other allergies. Also, tell your doctor if you have had serious side effects from similar medications (such as other decongestants, including phenylephrine). This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, difficulty urinating (such as due to an enlarged prostate), high blood pressure (hypertension), heart/blood vessel disease (such as coronary artery disease), overactive thyroid (hyperthyroidism), diabetes,...
Last reviewed on RxList: 4/29/2008
This monograph has been modified to include the generic and brand name in many instances.
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