Amphotericin B Phospholipid Complex

Reviewed on 4/25/2022

What Is Amphotericin B Phospholipid Complex and How Does It Work?

Amphotericin B Phospholipid Complex is a prescription medication used for treating systemic fungal infections.

What Are Dosages of Amphotericin B Phospholipid Complex?

Adult and pediatric dosage

Injectable, lipid complex

  • 5mg/mL

Systemic Fungal Infection

Adult and pediatric dosage

  • 5 mg/kg IV every day; infuse IV at rate of 2.5 mg/kg/hr

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Are Side Effects Associated with Using Amphotericin B Phospholipid Complex?

Common side effects of Amphotericin B Phospholipid Complex include:

  • fever,
  • chills,
  • nausea,
  • vomiting, and
  • abnormal kidney function tests.

Serious side effects of Amphotericin B Phospholipid Complex include:

  • hives,
  • difficulty breathing,
  • swelling of the face, lips, tongue, or throat,
  • fever,
  • lightheadedness,
  • shortness of breath,
  • new or worsening cough,
  • wheezing,
  • trouble breathing,
  • blue lips,
  • blue-colored fingers or toes,
  • easy bruising,
  • unusual bleeding,
  • purple or red spots under the skin,
  • slow heart rate,
  • weak pulse,
  • fainting,
  • slow breathing (breathing may stop),
  • little or no urinating,
  • swelling in the feet or ankles,
  • tiredness,
  • shortness of breath,
  • muscle spasms or contractions,
  • numbness or tingling,
  • dizziness,
  • irregular heartbeats,
  • feeling jittery,
  • muscle cramps,
  • cough or choking feeling,
  • leg cramps,
  • constipation,
  • fluttering in the chest,
  • increased thirst or urination, and
  • muscle weakness or limp feeling.

Rare side effects of Amphotericin B Phospholipid Complex include:

  • none 
This is not a complete list of side effects and other serious side effects or health problems that may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

SLIDESHOW

Fungal Skin Infections: Types, Symptoms, and Treatments See Slideshow

What Other Drugs Interact with Amphotericin B Phospholipid Complex?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Amphotericin B Phospholipid Complex has no noted severe interactions with any other drugs.
  • Amphotericin B Phospholipid Complex has no noted serious interactions with any other drugs.
  • Amphotericin B Phospholipid Complex has no noted moderate interactions with any other drugs.
  • Amphotericin B Phospholipid Complex has no noted minor interactions with any other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Amphotericin B Phospholipid Complex?

Contraindications

  • Hypersensitivity

Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Amphotericin B Phospholipid Complex?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Amphotericin B Phospholipid Complex?”

Cautions

  • Indicated for patients with progressive and potentially fatal fungal infections
  • Do not use for noninvasive fungal infections (e.g., oral thrush, vaginal candidiasis, esophageal candidiasis) in patients with normal neurophil counts

Pregnancy and Lactation

  • May be acceptable during pregnancy
  • Lactation
    • Unknown whether distributed in breast milk, caution advised
References
Medscape. Amphotericin B Phospholipid Complex.

https://reference.medscape.com/drug/abelcet-amphoterin-b-phospholipid-complex-999575#6

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