Abrilada vs. Humira

Are Abrilada and Humira the Same Thing?

Abrilada (adalimumab-afzb) and Humira (adalimumab) are tumor necrosis factor (TNF) blockers used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, and Crohn's disease.

Abrilada is also used to treat adult ulcerative colitis.

Abrilada is biosimilar to Humira (adalimumab).

Side effects of Abrilada and Humira that are similar include injection site reactions (redness, itching, pain, bruising, swelling, or bleeding) and headache.

Side effects of Abrilada that are different from Humira include infections (e.g. upper respiratory, sinusitis) and rash.

Side effects of Humira that are different from Abrilada include stuffy nose, sinus pain, and stomach pain.

Both Abrilada and Humira may interact with abatacept, anakinra, and live vaccines.

Abrilada may also interact with warfarin, cyclosporine, and theophylline.

Humira may also interact with etanercept, azathioprine, mercaptopurine, certolizumab, golimumab, infliximab, and rituximab.

What Are Possible Side Effects of Abrilada?

Side effects of Abrilada include:

  • Infections (e.g. upper respiratory, sinusitis),
  • injection site reactions,
  • headache, and
  • rash

What Are Possible Side Effects of Humira?

Common side effects of Humira include:

  • injection site reactions (redness, itching, pain, bruising, swelling, or bleeding),
  • headache,
  • suffy nose,
  • sinus pain, or
  • stomach pain.

Tell your doctor if you have serious side effects of Humira including:

  • fast/irregular/pounding heartbeat,
  • stomach pain,
  • blood in the stools,
  • mental/mood changes,
  • severe headache,
  • easy bruising or bleeding,
  • dark urine,
  • yellowing eyes and skin,
  • leg pain or swelling,
  • numbness or tingling of the arms/hands/legs/feet,
  • unsteadiness,
  • unexplained muscle weakness,
  • difficulty with speaking/chewing/swallowing/facial movements,
  • vision changes,
  • extreme fatigue,
  • joint pain, or
  • butterfly-shaped rash on the nose and cheeks.


What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, Diagnosis See Slideshow

What Is Abrilada?

Abrilada (adalimumab-afzb) is a tumor necrosis factor (TNF) blocker used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult Crohn's disease, ulcerative colitis and plaque psoriasis. Abrilada is biosimilar to Humira (adalimumab).

What Is Humira?

Humira (adalimumab) is an injectable protein (antibody) used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. Humira is also used to treat Crohn's disease after other drugs have been tried without successful treatment of symptoms.

What Drugs Interact With Abrilada?

Abrilada may interact with other medicines such as:

  • abatacept,
  • anakinra,
  • warfarin,
  • cyclosporine,
  • theophylline, and
  • live vaccines

Tell your doctor all medications and supplements you use and all vaccines you recently received.

What Drugs Interact With Humira?

Humira may interact with azathioprine or mercaptopurine. Asacol may also interact with pentamidine, tacrolimus, amphotericin B, antibiotics, antiviral medicines, cancer medicine, or aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs).

Humira may also interact with abatacept, anakinra, infliximab, etanercept, certolizumab pegol, golimumab, or rituximab.


The term arthritis refers to stiffness in the joints. See Answer

How Should Abrilada Be Taken?

The dose of Abrilada to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis is 40 mg every other week. The dose of Abrilada to treat juvenile idiopathic arthritis in children is based on the child's body weight. The initial dose (Day 1) of Abrilada to treat adult Crohn's disease and ulcerative is 160 mg (four 40 mg injections in one day or two 40 mg injections per day for two consecutive days). The second dose two weeks later (Day 15) is 80 mg. Two weeks later (Day 29), begin a maintenance dose of 40 mg every other week. The dose of Abrilada to treat plaque psoriasis is 80 mg initial dose, followed by 40 mg every other week starting one week after the initial dose.

How Should Humira Be Taken?

Humira is given by an injection under the skin. Your doctor will tell you how often to take an injection of Humira. This is based on your condition to be treated. Do not inject Humira more often than you were prescribed.

Do not try to inject Humira yourself until you have been shown the right way to give the injections. If your doctor decides that you or a caregiver may be able to give your injections of Humira at home, you should receive training on the right way to prepare and inject Humira.

Do not miss any doses of Humira unless your doctor says it is okay. If you forget to take Humira, inject a dose as soon as you remember. Then, take your next dose at your regular scheduled time. This will put you back on schedule.

In case you are not sure when to inject Humira, call your doctor or pharmacist.

If you take more Humira than you were told to take, call your doctor.


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Pfizer. Abrilada Product Information.


Abbvie. Humira Product Monograph.


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