Are Abrilada and Rinvoq the Same Thing?
Abrilada (adalimumab-afzb) and Rinvoq (upadacitinib) are used to treat rheumatoid arthritis.
Abrilada is also used to treat juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult Crohn's disease, ulcerative colitis and plaque psoriasis.
Rinvoq is used in adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate.
Abrilada is biosimilar to Humira (adalimumab).
Abrilada and Rinvoq belong to different drug classes. Abrilada is a tumor necrosis factor (TNF) blocker and Rinvoq is a Janus kinase (JAK) inhibitor.
Side effects of Abrilada and Rinvoq that are similar include infections (e.g. upper respiratory, sinusitis).
Side effects of Abrilada that are different from Rinvoq include injection site reactions, headache, and rash.
Side effects of Rinvoq that are different from Abrilada include nausea, cough, and fever.
Both Abrilada and Rinvoq may interact with live vaccines.
Abrilada may also interact with abatacept, anakinra, warfarin, cyclosporine, and theophylline.
Rinvoq may also interact with strong CYP3A4 inhibitors (e.g., ketoconazole) and strong CYP3A4 inducers (e.g., rifampin).
What Are Possible Side Effects of Abrilada?
Side effects of Abrilada include:
- Infections (e.g. upper respiratory, sinusitis),
- injection site reactions,
- headache, and
What Are Possible Side Effects of Rinvoq?
Common side effects of Rinvoq include:
- upper respiratory tract infections,
- cough, and
What Is Abrilada?
Abrilada (adalimumab-afzb) is a tumor necrosis factor (TNF) blocker used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult Crohn's disease, ulcerative colitis and plaque psoriasis. Abrilada is biosimilar to Rinvoq (adalimumab).
What Is Rinvoq?
Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor indicated for the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate.
What Drugs Interact With Abrilada?
Abrilada may interact with other medicines such as:
- theophylline, and
- live vaccines
Tell your doctor all medications and supplements you use and all vaccines you recently received.
What Drugs Interact With Rinvoq?
Rinvoq may interact with strong CYP3A4 inhibitors (e.g., ketoconazole), strong CYP3A4 inducers (e.g., rifampin), and live vaccines. Tell your doctor all medications and supplements you use. Rinvoq is not recommended for use during pregnancy; it may harm a fetus. Females of reproductive potential are advised to use effective contraception during treatment with Rinvoq and for 4 weeks following completion of therapy. It is unknown if Rinvoq passes into breast milk. Because of the potential for serious adverse reactions in the breastfed infant, breastfeeding is not recommended during treatment with Rinvoq, and for 6 days after the last dose.
How Should Abrilada Be Taken?
The dose of Abrilada to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis is 40 mg every other week. The dose of Abrilada to treat juvenile idiopathic arthritis in children is based on the child's body weight. The initial dose (Day 1) of Abrilada to treat adult Crohn's disease and ulcerative is 160 mg (four 40 mg injections in one day or two 40 mg injections per day for two consecutive days). The second dose two weeks later (Day 15) is 80 mg. Two weeks later (Day 29), begin a maintenance dose of 40 mg every other week. The dose of Abrilada to treat plaque psoriasis is 80 mg initial dose, followed by 40 mg every other week starting one week after the initial dose.
How Should Rinvoq Be Taken?
The recommended dose of Rinvoq is 15 mg once daily. Rinvoq may be used as monotherapy or in combination with methotrexate or other nonbiologic DMARDs.
Rheumatoid Arthritis Resources
Health Solutions From Our Sponsors
All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).
Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.
Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.
The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.
As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.
Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.
If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.
You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.
Pfizer. Abrilada Product Information.
FDA. Rinvoq Product Information.