Abrilada vs. Xeljanz

Abrilada (adalimumab-afzb) and Xeljanz (tofacitinib citrate) are used to treat rheumatoid arthritis.

Abrilada is also used to treat juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult Crohn's disease, ulcerative colitis and plaque psoriasis.

Xeljanz is used in adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate.

Abrilada is biosimilar to Humira (adalimumab).

Abrilada and Xeljanz belong to different drug classes. Abrilada is a tumor necrosis factor (TNF) blocker and Xeljanz is a Janus kinase (JAK) inhibitor.

Side effects of Abrilada and Xeljanz that are similar include infections (e.g. upper respiratory, sinusitis) and headache.

Side effects of Abrilada that are different from Xeljanz include injection site reactions and rash.

Side effects of Xeljanz that are different from Abrilada include diarrhea and cold symptoms such as sore throat, runny or stuffy nose.

Abrilada may interact with abatacept, anakinra, warfarin, cyclosporine, theophylline, and live vaccines.

Xeljanz may interact with aprepitant, bosentan, conivaptan, haloperidol, imatinib, isoniazid, St. John's wort, ticlopidine, antibiotics, antidepressants, antifungals, hepatitis C medications boceprevir or telaprevir, heart or blood pressure medicines, HIV or AIDS medicines, medications to treat excess stomach acid, medicines to prevent organ transplant rejection, nonsteroidal anti-inflammatory drugs (NSAIDs), other arthritis medications, seizure medications, and steroids.

Side effects of Abrilada include:

• Infections (e.g. upper respiratory, sinusitis),
• injection site reactions,
• headache, and
• rash

Common side effects of Xeljanz include:

• upper respiratory tract infections,
• headache,
• diarrhea, and
• cold symptoms such as sore throat, runny or stuffy nose.

Tell your doctor if you experience serious side effects of Xeljanz including:

• feeling very tired,
• yellow skin or eyes (jaundice),
• loss of appetite,
• vomiting,
• dark urine,
• clay-colored stool,
• skin rash,
• clay-colored stools,
• skin rash,
• fever or chills,
• night sweats,
• weight loss,
• changes in bowel habits,
• pain or burning when you urinate,
• sores in your mouth or throat,
• stabbing chest pain,
• shortness of breath,
• cough with mucus or blood, or
• skin redness or swelling.

Abrilada (adalimumab-afzb) is a tumor necrosis factor (TNF) blocker used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult Crohn's disease, ulcerative colitis and plaque psoriasis. Abrilada is biosimilar to Xeljanz (adalimumab).

Xeljanz (tofacitinib citrate) is a Janus kinase (JAK) inhibitor used to treat adults with moderate to severely active rheumatoid arthritis (RA) who have not responded well to methotrexate, or cannot tolerate it.

Abrilada may interact with other medicines such as:

• abatacept,
• anakinra,
• warfarin,
• cyclosporine,
• theophylline, and
• live vaccines

Tell your doctor all medications and supplements you use and all vaccines you recently received.

Xeljanz may interact with aprepitant, bosentan, conivaptan, haloperidol, imatinib, isoniazid, St. John's wort, ticlopidine, antibiotics, antidepressants, antifungals, hepatitis C medications boceprevir or telaprevir, heart or blood pressure medicines, HIV or AIDS medicines, medications to treat excess stomach acid, medicines to prevent organ transplant rejection, nonsteroidal anti-inflammatory drugs (NSAIDs), other arthritis medications, seizure medications, or steroids. Tell your doctor all medications and supplements you use.

The dose of Abrilada to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis is 40 mg every other week. The dose of Abrilada to treat juvenile idiopathic arthritis in children is based on the child's body weight. The initial dose (Day 1) of Abrilada to treat adult Crohn's disease and ulcerative is 160 mg (four 40 mg injections in one day or two 40 mg injections per day for two consecutive days). The second dose two weeks later (Day 15) is 80 mg. Two weeks later (Day 29), begin a maintenance dose of 40 mg every other week. The dose of Abrilada to treat plaque psoriasis is 80 mg initial dose, followed by 40 mg every other week starting one week after the initial dose.

The recommended dose of Xeljanz is 5 mg twice daily.