What is Accuzyme and how is it used?
Accuzyme is a prescription medicine used for wound debridement caused by pressure ulcer, burns, postoperative wounds and miscellaneous traumatic or infected wounds. Accuzyme may be used alone or with other medications.
Accuzyme belongs to a class of drugs called Topical Debriding Agents.
It is not known if Accuzyme is safe and effective in children.
What are the possible side effects of Accuzyme?
Accuzyme may cause serious side effects including:
- difficulty breathing,
- swelling of your face, lips, tongue, or throat,
- itching, and
Get medical help right away, if you have any of the symptoms listed above.
The most common side effects of Accuzyme include:
- mild stinging or burning, and
- skin irritation
Tell the doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Accuzyme. For more information, ask your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
ACCUZYME (papain and urea) enzymatic debriding ointment contains papain, USP (8.3 x 105 USP units of activity per gram) and urea, USP 10% in a hydrophilic ointment base composed of emulsifying wax, fragrance, glycerin, isopropyl palmitate, lactose, methylparaben, potassium phosphate monobasic, propylparaben, and purified water.
ACCUZYME (papain and urea) is indicated for debridement of necrotic tissue and liquefication of slough in acute and chronic lesions such as pressure ulcers, varicose and diabetic ulcers, burns, postoperative wounds, pilonidal cyst wounds, carbuncles and miscellaneous traumatic or infected wounds.
DOSAGE AND ADMINISTRATION
Cleanse the wound with ALLCLENZ® Wound Cleanser or saline. Avoid cleansing with hydrogen peroxide solution as it may inactivate the papain. Apply ACCUZYME (papain and urea) directly to the wound, cover with appropriate dressing, secure into place. Daily or twice daily applications are preferred. Irrigate the wound at each redressing to remove any accumulation of liquefied necrotic material. NOTE: Papain may also be inactivated by the salts of heavy metals such as lead, silver and mercury. Contact with medications containing these metals should be avoided.
30g tube, 6g tube. Store in a cool place 8°-15°C (46°-59°F).
Do not refrigerate.
ACCUZYME (papain and urea) Ointment is a registered trademark of Healthpoint, Ltd.
ALLCLENZ Wound Cleanser is a registered trademark of Healthpoint, Ltd.
|Marketed by: |
Fort Worth, Texas 76107
|Manufactured by: |
DPT Laboratories, Ltd.
San Antonio, Texas 78215
REORDER NO. 0064-1000-01 (30g tube)
0064-1000-07 (6g tube)
ACCUZYME (papain and urea) Ointment is generally well-tolerated and non-irritating. A transient "burning" sensation may be experienced by a small percentage of patients upon applying ACCUZYME (papain and urea) Ointment. Occasionally, the profuse exudate from enzymatic digestion may irritate the skin. In such cases, more frequent dressing changes will alleviate discomfort until exudate decreases.
No Information Provided.
No Information Provided.
See Dosage and Administration . Not to be used in eyes.
Papain, the proteolytic enzyme from the fruit of carica papaya, is a potent digestant of nonviable protein matter but is harmless to viable tissue. It is active over a pH range of 3 to 12. Papain is relatively ineffective when used alone as a debriding agent and requires the presence of activators to stimulate its digestive potency. In ACCUZYME (papain and urea) , papain is combined with urea, a denaturant of proteins, to bring about two supplemental chemical actions: (1) to expose by solvent action the activators of papain, and (2) to denature the nonviable protein matter in lesions and thereby render it more susceptible to enzymatic digestion. Pharmacologic studies have shown that the combination of papain and urea result in twice as much digestive activity as papain alone.
Skin Problems and Treatments Resources
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.