Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 2/23/2022
Accuzyme Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Accuzyme?

Accuzyme (papain and urea) enzymatic debriding ointment is used to break down dead skin or tissues in wounds such as bed sores, ulcers, burns, surgical wounds, cysts, and carbuncles. Accuzyme may be available in generic form.

What Are Side Effects of Accuzyme?

Common side effects of Accuzyme include

    mild stinging or burning of the skin or skin irritation where the medicine is applied.

    Tell your doctor if you experience side effects of a severe allergic reaction to Accuzyme including rash, hives, itching, difficulty breathing, or swelling.

    Dosage for Accuzyme

    Apply a dose of Accuzyme directly to the wound, cover with appropriate dressing, secure into place. Daily or twice daily applications are preferred.

    What Drugs, Substances, or Supplements Interact with Accuzyme?

    Accuzyme may interact with hydrogen peroxide applied to the wound area. Tell your doctor all medications and supplements you use.

    Accuzyme During Pregnancy or Breastfeeding

    It is unknown if Accuzyme will be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

    Additional Information

    Our Accuzyme (papain and urea) enzymatic debriding ointment Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Accuzyme Professional Information


ACCUZYME (papain and urea) Ointment is generally well-tolerated and non-irritating. A transient "burning" sensation may be experienced by a small percentage of patients upon applying ACCUZYME (papain and urea) Ointment. Occasionally, the profuse exudate from enzymatic digestion may irritate the skin. In such cases, more frequent dressing changes will alleviate discomfort until exudate decreases.

Read the entire FDA prescribing information for Accuzyme (Papain and Urea)


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© Accuzyme Patient Information is supplied by Cerner Multum, Inc. and Accuzyme Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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