Acetaminophen Chlorpheniramine

What Is Acetaminophen/Chlorpheniramine Used For and How Does it Work?

Acetaminophen/chlorpheniramine is an over-the-counter (OTC) product used for the relief of cold and flu symptoms.

Acetaminophen/chlorpheniramine is available under the following different brand names: Coricidin HBP Cold & Flu and St. Joseph Cold & Flu.

What Are the Dosages of Acetaminophen/Chlorpheniramine?

Dosages of Acetaminophen/Chlorpheniramine:

Dosage Forms and Strengths


  • 325mg/2mg

Dosage Considerations – Should be Given as Follows:

Relief of Cold and Flu Symptoms

  • Adults and children 12 years and older: 2 tablets orally every 4 hours

Hepatic Impairment

  • May tolerate low dose therapy but use caution; cases of hepatotoxicity at doses less than 4 g/day reported

What Are Side Effects Associated with Using Acetaminophen/Chlorpheniramine?

Common side effects of Acetaminophen/Chlorpheniramine include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Acetaminophen/Chlorpheniramine?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Acetaminophen/chlorpheniramine has no listed severe interactions with other drugs.

Serious interactions of acetaminophen/chlorpheniramine include:

Acetaminophen/phenyltoloxamine has no listed moderate interactions with other drugs.

Acetaminophen/phenyltoloxamine has no listed mild interactions with other drugs.

What Are Warnings and Precautions for Acetaminophen/Chlorpheniramine?


This medication contains acetaminophen/chlorpheniramine. Do not take Coricidin HBP Cold & Flu or St. Joseph Cold & Flu if you are allergic to acetaminophen/chlorpheniramine or any ingredients contained in this drug.


  • Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency
  • Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates
  • Acetaminophen hepatotoxicity is possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose
  • Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGE); symptoms may include skin redness, blisters, and rash

Effects of Drug Abuse

  • No information is available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Acetaminophen/Chlorpheniramine?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Acetaminophen/Chlorpheniramine?"


  • No information available

Pregnancy and Lactation

Three is no information available regarding the use of acetaminophen/chlorpheniramine during pregnancy or while breastfeeding. Pregnant or breastfeeding patients should seek the advice of a health professional before using over-the-counter (OTC) drugs.


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