Acetaminophen Rectal

What Is Acetaminophen Rectal Used For and How Does it Work?

Acetaminophen rectal is an over-the-counter (OTC) product used as a fever reducer/pain reliever (antipyretic/analgesic).

Acetaminophen rectal is available under the following different brand names: Acephen, FeverAll, FeverAll Infants, FeverAll Junior Strength, and Adults' FeverAll.

Dosages of Acetaminophen Rectal

Dosage Forms and Strengths


  • 80mg
  • 120mg
  • 325mg
  • 650mg

Dosage Considerations – Should be Given as Follows:


  • Adults and children over 12 years: 325-650 mg rectally every 4-6 hours as needed. Not to exceed 4 g/day.
  • 6-12 years: 325 mg rectally every 4-6 hours as needed
  • 3-6 years: 120 mg rectally every 4-6 hours as needed
  • 1-3 years: 80 mg rectally every 4 hours as needed
  • 3 months to 1 year: 80 mg rectally every 6 hours as needed

Maximum daily dose

  • Children under 12 years: Not to exceed 5 doses/24 hours


  • Patient should lie on left side with knees bent
  • Remove protective wrap before inserting
  • Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)

What Are Side Effects Associated with Using Acetaminophen Rectal?

Common side effects of acetaminophen_rectal include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Acetaminophen Rectal?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Acetaminophen rectal has no listed severe interactions with other drugs.
  • Acetaminophen rectal has no listed serious interactions with other drugs.
  • Moderate interactions of acetaminophen rectal include:
  • Acetaminophen rectal has mild interactions with at least 54 different drugs.

What Are Warnings and Precautions for Acetaminophen Rectal?


This medication contains acetaminophen rectal. Do not take Acephen, FeverAll, FeverAll Infants, FeverAll Junior Strength, or Adults' FeverAll if you are allergic to acetaminophen rectal or any ingredients contained in this drug.


  • Hypersensitivity

Effects of Drug Abuse

  • No information available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Acetaminophen Rectal?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Acetaminophen Rectal?"


  • Acetaminophen is available in many dosage forms and products, check label carefully to avoid overdose
  • Risk of hepatotoxicity is higher in alcoholics, chronic high dose, or use of more than one acetaminophen-containing product
  • G6PD deficiency
  • Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash

Pregnancy and Lactation

Acetaminophen rectal may be acceptable for use during pregnancy. Either animal studies show no risk but human studies are not available or animal studies showed minor risks and human studies were done and showed no risk. Acetaminophen rectal crosses the placenta, but is considered safe to use in all stages of pregnancy short term. Consult your doctor.

Acetaminophen rectal is excreted in breast milk. Acetaminophen rectal is compatible with breastfeeding.

Pregnant or breastfeeding patients should seek advice of a health professional before using over-the-counter (OTC) drugs.


Health Solutions From Our Sponsors