Aciphex vs. Dexilant

Are Aciphex and Dexilant the Same Thing?

Aciphex (rabeprazole sodium) and Dexilant (dexlansoprazole) are proton pump inhibitors (PPIs) used to reduce stomach acid to treat gastroesophageal reflux disease (GERD) and duodenal ulcers.

Aciphex is also used in combination with antibiotics to treat Helicobacter pylori (H. pylori) bacterial infections in the stomach.

Side effects of Aciphex and Dexilant that are similar include diarrhea and gas.

Side effects of Aciphex that are different from Dexilant include rash or itching, upset stomach, sore throat, headache, insomnia, and nervousness.

Side effects of Dexilant that are different from Aciphex include nausea, vomiting, stomach pain, stuffy nose, sneezing, and other cold symptoms.

Both Aciphex and Dexilant may interact with the HIV medication atazanavir, blood thinners, digoxin, and ketoconazole.

Aciphex may also interact with diuretics (water pills), methotrexate, and cyclosporine.

Dexilant may also interact with ampicillin esters, iron salts, tacrolimus, and clopidogrel.

What Are Possible Side Effects of Aciphex?

Common side effects of Aciphex include:

  • rash or itching,
  • upset stomach,
  • diarrhea,
  • gas,
  • sore throat,
  • headache,
  • insomnia, or
  • nervousness.

Serious side effects of Aciphex include:

What Are Possible Side Effects of Dexilant?

Common side effects of Dexilant include:

  • diarrhea,
  • nausea,
  • vomiting,
  • stomach pain,
  • gas,
  • stuffy nose,
  • sneezing, or
  • other cold symptoms

What Is Aciphex?

Aciphex (rabeprazole sodium) is a proton pump inhibitor (PPI) to reduce stomach acid and is used for the treatment of gastroesophageal reflux disease (GERD), duodenal ulcers, and used in combination with antibiotics to treat Helicobacter pylori (H. pylori) bacterial infections in the stomach.

What Is Dexilant?

Dexilant (dexlansoprazole) is a proton pump inhibitor (PPI) used to treat certain stomach and esophagus problems (such as acid reflux). It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough.


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What Drugs Interact With Aciphex?

Aciphex may interact with atazanavir, blood thinners, digoxin, diuretics (water pills), ketoconazole, or methotrexate.

Aciphex may also interact with cyclosporine.

What Drugs Interact With Dexilant?

Dexilant may interact with atazanavir, ampicillin, digoxin, iron, blood thinners such as warfarin, or ketoconazole.

Dexilant may also interact with digoxin, tacrolimus, or clopidogrel.

How Should Aciphex Be Taken?

  • Take Aciphex exactly as prescribed. Your doctor will prescribe the dose that is right for you and your medical condition. Do not change your dose or stop taking Aciphex unless you talk to your doctor. Take Aciphex for as long as it is prescribed even if you feel better.
  • Aciphex is usually taken 1 time each day. Your doctor will tell you the time of day to take Aciphex, based on your medical condition.
  • Aciphex can be taken with or without food. Your doctor will tell you whether to take this medicine with or without food based on your medical condition.
  • Swallow each Aciphex tablet whole. Do not chew, crush, or split Aciphex tablets. Tell your doctor if you cannot swallow tablets whole.
  • If you miss a dose of Aciphex, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your normal schedule. Do not take 2 doses at the same time.
  • If you take too much Aciphex, call your doctor or your poison control center at 1-800-222-1222 right away, or go to the nearest hospital emergency room.
  • Your doctor may prescribe antibiotic medicines with Aciphex to help treat a stomach infection and heal stomach (duodenal) ulcers that are caused by bacteria called H. pylori. Make sure you read the patient information that comes with an antibiotic before you start taking it.

How Should Dexilant Be Taken?

The recommended dosage of Dexilant is 30 mg once daily for up to 6 months for maintenance of healed EE, and 30 mg once daily for 4 weeks to treat symptomatic non-erosive GERD.


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Eisai. AcipHex Product Information.

Takeda Pharmaceuticals U.S.A. Dexilant Prescribing Information.

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