Actos vs. Invokana

Are Actos and Invokana the Same Thing?

Actos (pioglitazone hydrochloride) and Invokana (canagliflozin) are used to manage type 2 diabetes.

Actos and Invokana belong to different drug classes. Actos is a thiazolidinedione and Invokana is a sodium-glucose co-transporter 2 (SGLT2) inhibitor.

What Are Possible Side Effects of Actos?

Common side effects of Actos include:

Tell your doctor if you have serious side effects of Actos including:

What Are Possible Side Effects of Invokana?

Common side effects of Invokana include:


Type 2 Diabetes: Signs, Symptoms, Treatments See Slideshow

What Is Actos?

Actos (pioglitazone hydrochloride) is a thiazolidinedione and increases the body's sensitivity to insulin. Actos is used for type 2 diabetes, not type 1 diabetes or diabetic ketoacidosis. Generic Actos is not available in the U.S., but is available in other countries as pioglitazone.

What Is Invokana?

Invokana (canagliflozin) is a sodium-glucose co-transporter 2 (SGLT2) inhibitor used to control blood sugar in people with type 2 diabetes mellitus, in addition to diet and exercise.

What Drugs Interact With Actos?

Actos and other similar drugs may exacerbate symptoms of congestive heart failure (dyspnea, edema, weight gain) and these symptoms may be serious. Patients with congestive heart failure classified as III or IV (NY Heart Association) should not take this Actos. Other serious side effects of Actos include nausea, vomiting, jaundice, and vision changes or loss; it may also cause hypoglycemia.

What Drugs Interact With Invokana?

Invokana may interact with rifampin or digoxin. Tell your doctor all medications you use. Invokana should only be given to a pregnant woman if the benefit of the drug justifies the risk of harm to the fetus.


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How Should Actos Be Taken?

Actos is available as tablets in strengths of 15, 30 or 45 mg. Dose is dependent on patient response and the prescribing doctor's clinical judgment; glucose tests may help determine doses.

How Should Invokana Be Taken?

The recommended starting dose of Invokana is 100 mg once daily, taken before the first meal of the day. Doses may be increased to 300 mg in patients who are able to tolerate Invokana at 100 mg doses.


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Takeda. Actos Product Information.
Janssen Pharmaceuticals, Inc.. Invokana Product Information.

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