Aczone (Dapzone) vs. Bactrim

Dapsone and Bactrim (sulfamethoxazole and trimethoprim) DS are antibiotics used to treat different conditions.

Dapsone is used in the treatment of dermatitis herpetiformis (a skin condition) and leprosy (Hansen's disease).

Bactrim is used to treat urinary tract infections, acute otitis media, bronchitis, Shigellosis, Pneumocystis pneumonia, traveler's diarrhea, methicillin-resistant Staphylococcus aureus (MRSA), and other bacterial infections.

A brand name for dapsone is Aczone.

Side effects of dapsone and Bactrim that are similar include nausea, vomiting, loss of appetite, dizziness, ringing in the ears, or sleep problems (insomnia).

Side effects of dapsone that are different from Bactrim include blurred vision, headache, or increased sensitivity of the skin to sunlight.

Side effects of Bactrim that are different from dapsone include painful or swollen tongue, spinning sensation, or tiredness.

Dapsone may interact with other drugs.

Bactrim may interact with leucovorin or methotrexate.

Side effects of Aczone include:

• skin dryness,
• redness,
• oiliness, and
• peeling.

Common side effects of Bactrim include:

• loss of appetite,
• nausea,
• vomiting,
• painful or swollen tongue,
• dizziness,
• spinning sensation,
• ringing in your ears,
• tiredness, or
• sleep problems (insomnia).

Tell your doctor if you experience serious side effects of Bactrim including:

• bruising or bleeding,
• aplastic anemia,
• jaundice,
• hepatic necrosis,
• mouth sores,
• joint aches,
• severe skin rashes,
• itching, and
• sore throat.

Aczone (dapsone) Gel, 5% is a sulfone drug indicated for the topical treatment of acne vulgaris. Aczone Gel 5% is available in generic form.

Bactrim (sulfamethoxazole and trimethoprim) DS is a combination of two antibiotics used to treat urinary tract infections, acute otitis media, bronchitis, Shigellosis, Pneumocystis pneumonia, traveler's diarrhea, methicillin-resistant Staphylococcus aureus (MRSA), and other bacterial infections susceptible to this antibiotic. Bactrim is available as a generic drug.

Aczone Gel 5% may interact with other topical medications, harsh or abrasive soaps, or cosmetics on the affected area. Tell your doctor all medications, supplements, and skin care products you use. Tell your doctor if you are pregnant or plan to become pregnant before using Aczone Gel 5%; it is unknown if it will harm a fetus. Aczone Gel 5% passes into breast milk and may affect a nursing baby. Consult your doctor before breastfeeding.

Bactrim may interact with blood thinners, cyclosporine, methotrexate, oral diabetes medications, and seizure medications.

Bactrim may also interact with antidepressants, digoxin, diuretics (water pills), indomethacin, leucovorin, calcium folinate, and heart or blood pressure medications.

For topical use only. Not for oral, ophthalmic, or intravaginal use. After the skin is gently washed and patted dry, apply approximately a pea-sized amount of Aczone Gel 5%, in a thin layer to the acne affected areas twice daily. Rub in Aczone Gel 5% gently and completely. Wash hands after application of Aczone Gel 5%.

Administer the solution by intravenous infusion over a period of 60 to 90 minutes. Avoid administration by rapid infusion or bolus injection. Do NOT administer Bactrim intramuscularly.