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Adderall

Last reviewed on RxList: 3/10/2017
Adderall Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 03/10/2017

Adderall (amphetamine and dextroamphetamine salts) is an amphetamine used for treating attention deficit hyperactivity disorder (ADHD) and narcolepsy. Side effects of Adderall include:

  • nervousness,
  • restlessness,
  • excitability,
  • irritability,
  • agitation,
  • dizziness,
  • headache,
  • fear,
  • anxiety,
  • agitation,
  • tremor,
  • weakness,
  • blurred vision,
  • sleep problems (insomnia),
  • dry mouth or unpleasant taste in the mouth,
  • diarrhea,
  • constipation,
  • stomach pain,
  • nausea,
  • vomiting,
  • fever,
  • hair loss,
  • loss of appetite,
  • weight loss,
  • loss of interest in sex,
  • impotence,
  • difficulty having an orgasm,
  • increase blood pressure,
  • increased heart rate, and
  • heart palpitations.

The usual dose of Adderall is 2.5-60 mg daily administered in one or three doses. Adderall may interact with heart or blood pressure medications, diuretics (water pills), cold or allergy medicines (antihistamines), acetazolamide, chlorpromazine, ethosuximide, haloperidol, lithium, meperidine, methenamine, phenytoin , phenobarbital, reserpine, ammonium chloride, ascorbic acid (vitamin C), potassium phosphate, antacids, sodium bicarbonate (Alka-Seltzer), potassium citrate, sodium citrate and citric acid, sodium citrate and potassium, stomach acid reducers, or antidepressants. Tell your doctor all medications and supplements you use. Adderall should not be used in pregnancy. Mothers taking Adderall should refrain from nursing because amphetamines are excreted in human milk and can have undesirable effects on the child. Adderall is habit forming and chronic use may lead to dependence.

Our Adderall Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Adderall Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • signs of heart problems--chest pain, trouble breathing, feeling like you might pass out;
  • signs of psychosis--hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;
  • signs of circulation problems--numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;
  • a seizure (convulsions);
  • muscle twitches (tics); or
  • changes in your vision.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Amphetamine and dextroamphetamine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

  • stomach pain, loss of appetite;
  • weight loss;
  • mood changes, feeling nervous;
  • fast heart rate;
  • headache, dizziness;
  • sleep problems (insomnia); or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Adderall (Amphetamine, Dextroamphetamine Mixed Salts)

Adderall Professional Information

SIDE EFFECTS

Cardiovascular

Palpitations, tachycardia, elevation of blood pressure, sudden death, myocardial infarction. There have been isolated reports of cardiomyopathy associated with chronic amphetamine use.

Central Nervous System

Psychotic episodes at recommended doses, overstimulation, restlessness, irritability, euphoria, dyskinesia, dysphoria, depression, tremor, tics, aggression, anger, logorrhea, dermatillomania.

Eye Disorders

Vision blurred, mydriasis.

Gastrointestinal

Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances. Anorexia and weight loss may occur as undesirable effects.

Allergic

Urticaria, rash, hypersensitivity reactions including angioedema and anaphylaxis. Serious skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported.

Endocrine

Impotence, changes in libido, frequent or prolonged erections.

Skin

Alopecia.

Musculoskeletal

Rhabdomyolysis.

Drug Abuse And Dependence

Adderall® (Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets) is a Schedule II controlled substance.

Amphetamines have been extensively abused. Tolerance, extreme psychological dependence, and severe social disability have occurred. There are reports of patients who have increased the dosage to levels many times higher than recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with amphetamines include severe dermatoses, marked insomnia, irritability, hyperactivity, and personality changes. The most severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia.

Read the entire FDA prescribing information for Adderall (Amphetamine, Dextroamphetamine Mixed Salts)

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