Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.

Addyi vs. Vyleesi

Are Addyi and Vyleesi the Same Thing?

Addyi (flibanserin) and Vyleesi (bremelanotide injection) are indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to: a co-existing medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance.

Addyi and Vyleesi belong to different drug classes. Addyi is a multifunctional serotonin agonist and antagonist (MSAA) and Vyleesi is a melanocortin receptor agonist.

Side effects of Addyi and Vyleesi that are similar include nausea.

Side effects of Addyi that are different from Vyleesi include dizziness, sleepiness, fatigue, insomnia, dry mouth, anxiety, constipation, abdominal pain, menstrual spotting, rash, sedation, and spinning sensation (vertigo).

Side effects of Vyleesi that are different from Addyi include flushing, injection site reactions (redness, bruising, itching, bleeding, and numbness), headache, and vomiting.

Addyi may interact with alcohol, CNS depressants (such as diphenhydramine, opioids, hypnotics, benzodiazepines), antifungals, antiviral drugs, grapefruit juice, oral contraceptives, cimetidine, ginkgo, ranitidine, proton pump inhibitors, selective serotonin reuptake inhibitors (SSRIs), some antibiotics, nefazodone, phenobarbital, St. Johns wort, digoxin, sirolimus, seizure medications, and some medicines used to treat high blood pressure, chest pain (angina), or other heart problems.

Vyleesi may interact with naltrexone and other drugs taken orally at the same time.

What Are Possible Side Effects of Addyi?

Common side effects of Addyi include:

  • dizziness,
  • sleepiness,
  • nausea,
  • fatigue,
  • insomnia, and
  • dry mouth

Other side effects of Addyi include:

What Are Possible Side Effects of Vyleesi?

Common side effects of Vyleesi include:

  • nausea,
  • flushing,
  • injection site reactions
    • redness,
    • bruising,
    • itching,
    • bleeding, and
    • numbness,
  • headache, and
  • vomiting

What Is Addyi?

Addyi (flibanserin) is a multifunctional serotonin agonist and antagonist (MSAA) indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to: a co-existing medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance.

What Is Vyleesi?

Vyleesi (bremelanotide injection) is a melanocortin receptor agonist indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to a co-existing medical or psychiatric condition, problems with the relationship, or the effects of a medication or drug substance.

QUESTION

Condoms are the best protection from sexually transmitted diseases (STDs). See Answer

What Drugs Interact With Addyi?

Addyi may interact with alcohol, CNS depressants (such as diphenhydramine, opioids, hypnotics, benzodiazepines), antifungals, antiviral drugs, grapefruit juice, oral contraceptives, cimetidine, fluoxetine, ginkgo, ranitidine, proton pump inhibitors, selective serotonin reuptake inhibitors (SSRIs), some antibiotics, nefazodone, carbamazepine, phenobarbital, phenytoin, St. Johns Wort, digoxin, sirolimus, and some medicines used to treat high blood pressure, chest pain (angina), or other heart problems. Tell your doctor all medications and supplements you use. Addyi is only available through the Addyi risk evaluation and mitigation strategy (REMS) Program because of the increased risk of severe low blood pressure and fainting (loss of consciousness) with alcohol use. You can only get Addyi from pharmacies that are enrolled in the Addyi REMS Program. Tell your doctor if you are pregnant or plan to become pregnant before using Addyi. It is unknown if Addyi will harm a fetus. Because of the potential for serious adverse reactions including sedation in a breastfed infant, breastfeeding is not recommended during treatment with Addyi.

What Drugs Interact With Vyleesi?

Vyleesi may interact with naltrexone and other drugs taken orally at the same time. Tell your doctor all medications and supplements you use. Vyleesi is not recommended for use during pregnancy; it may harm a fetus. Females of reproductive potential are advised to use effective contraception while using Vyleesi. There will be a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Vyleesi during pregnancy. It is unknown if Vyleesi passes into breast milk. Consult your doctor before breastfeeding.

How Should Addyi Be Taken?

The recommended dosage of Addyi is 100 mg taken once daily at bedtime.

How Should Vyleesi Be Taken?

The dose of Vyleesi is 1.75 mg injected subcutaneously via the autoinjector to the abdomen or thigh, as needed, at least 45 minutes before anticipated sexual activity.

SLIDESHOW

Erectile Dysfunction (ED) Causes and Treatment See Slideshow
Reviewed on 7/30/2019
References


Sprout Pharmaceuticals. Addyi Product Information.

https://addyi.com

AMAG Pharmaceuticals. Vyleesi Product Information.

https://www.vyleesi.com
CONTINUE SCROLLING FOR RELATED SLIDESHOW

Health Solutions From Our Sponsors