Last updated on RxList: 2/19/2021
Adenoscan Side Effects Center

What Is Adenoscan?

Adenoscan (adenosine injection) is a vasodilator used in combination with thallium-201 for nuclear heart stress tests when the patient is unable to exercise adequately.

What Are Side Effects of Adenoscan?

Common side effects include:

  • flushing,
  • chest discomfort,
  • shortness of breath,
  • throat/neck/jaw discomfort,
  • abdominal pain or discomfort,
  • lightheadedness,
  • dizziness,
  • nausea,
  • headache,
  • upset stomach,
  • pain at injection site,
  • discomfort of the arms and hands,
  • weakness,
  • low blood pressure (hypotension),
  • nervousness, and
  • irregular heart beat

Serious events have occurred with Adenoscan, such as fatal cardiac arrest, life-threatening ventricular arrhythmias, and heart attack.

Dosage for Adenoscan

The recommended intravenous dose of Adenoscan for adults is 140 mcg/kg/min infused for six minutes (total dose of 0.84 mg/kg). Tell your doctor all medications you are taking.

What Drugs, Substances, or Supplements Interact with Adenoscan?

Avoid drinking large amounts of caffeine (such as in coffee, tea, or some soft drinks).

Adenoscan During Pregnancy and Breastfeeding

No studies have been performed in pregnant women; Adenoscan should only be used during pregnancy if the benefits outweigh the risks. Discuss with your doctor the risks of breastfeeding and use of Adenoscan.

Additional Information

Our Adenoscan (adenosine) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer
Adenoscan Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • severe shortness of breath;
  • chest pain or tightness, pain spreading to your jaw or shoulder;
  • fluttering in your chest;
  • a light-headed feeling, like you might pass out;
  • a seizure;
  • severe headache, blurred vision, pounding in your neck or ears; or
  • sudden numbness or weakness, problems with vision or speech.

Common side effects may include:

  • flushing (sudden warmth, redness, or tingly feeling);
  • chest pressure, shortness of breath;
  • nausea;
  • headache, dizziness; or
  • discomfort in your neck or jaw.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Adenoscan (Adenosine Injection)


Heart Disease: Symptoms, Signs, and Causes See Slideshow
Adenoscan Professional Information


The following reactions with an incidence of at least 1% were reported with intravenous Adenoscan among 1421 patients enrolled in controlled and uncontrolled U.S. clinical trials. Despite the short half-life of adenosine, 10.6% of the side effects occurred not with the infusion of Adenoscan but several hours after the infusion terminated. Also, 8.4% of the side effects that began coincident with the infusion persisted for up to 24 hours after the infusion was complete. In many cases, it is not possible to know whether these late adverse events are the result of Adenoscan infusion.

Flushing 44%
Chest discomfort 40%
Dyspnea or urge to breathe deeply 28%
Headache 18%
Throat, neck or jaw discomfort 15%
Gastrointestinal discomfort 13%
Lightheadedness/dizziness 12%
Upper extremity discomfort 4%
ST segment depression 3%
First-degree AV block 3%
Second-degree AV block 3%
Paresthesia 2%
Hypotension 2%
Nervousness 2%
Arrhythmias 1%

Adverse experiences of any severity reported in less than 1% of patients include:

Body as a Whole

Back discomfort; lower extremity discomfort; weakness

Cardiovascular System

Nonfatal myocardial infarction; life-threatening ventricular arrhythmia; third-degree AV block; bradycardia; palpitation; sinus exit block; sinus pause; sweating; T-wave changes; hypertension (systolic blood pressure > 200 mm Hg)

Central Nervous System

Drowsiness; emotional instability; tremors

Genital/Urinary System

Vaginal pressure; urgency

Respiratory System


Special Senses

Blurred vision; dry mouth; ear discomfort; metallic taste; nasal congestion; scotomas; tongue discomfort

Post Marketing Experience


The following adverse events have been reported from marketing experience with Adenoscan. Because these events are reported voluntarily from a population of uncertain size, are associated with concomitant diseases and multiple drug therapies and surgical procedures, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Decisions to include these events in labeling are typically based on one or more of the following factors: (1) seriousness of the event, (2) frequency of the reporting, (3) strength of causal connection to the drug, or a combination of these factors.

Body as a Whole

Injection site reaction

Cardiovascular System

Fatal and nonfatal cardiac arrest, myocardial infarction, ventricular arrhythmia

Central Nervous System

Seizure activity, including tonic clonic (grand mal) seizures, and loss of consciousness


Nausea and vomiting


Respiratory arrest, throat tightness

Read the entire FDA prescribing information for Adenoscan (Adenosine Injection)


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© Adenoscan Patient Information is supplied by Cerner Multum, Inc. and Adenoscan Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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