Adrenaclick Side Effects Center

Last updated on RxList: 10/25/2022
Adrenaclick Side Effects Center

What Is Adrenaclick?

Adrenaclick (epinephrine) Auto-injector is a sympathomimetic catecholamine used in the emergency treatment of severe allergic reactions (Type I) including anaphylaxis to stinging or biting insects, allergen immunotherapy, foods, drugs, diagnostic testing substances, and other allergens, as well as anaphylaxis to unknown substances, or exercise-induced anaphylaxis. Adrenaclick is intended for immediate administration in patients with a history of anaphylactic reactions.

What Are Side Effects of Adrenaclick?

Adrenaclick may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat, and
  • pain, swelling, warmth, redness, or other signs of infection around the area where you gave an injection

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Adrenaclick include:

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Adrenaclick

Adrenaclick is capable of delivering one dose of either 0.15 mg or 0.3 mg (0.15 mL or 0.3 mL) of epinephrine. This dose is available for auto-injection by the patient. Selection of the appropriate Adrenaclick dosage strength is determined according to patient body weight.

What Drugs, Substances, or Supplements Interact with Adrenaclick?

Adrenaclick may interact with cardiac glycosides, diuretics, antidepressants, monoamine oxidase inhibitors, sodium levothyroxine, antihistamines, beta-blockers, alpha-blockers, ergot alkaloids, and phenothiazines. Tell your doctor all medications and supplements you use.

Adrenaclick During Pregnancy and Breastfeeding

During pregnancy, Adrenaclick should be used only if prescribed. Consult your doctor before breastfeeding.

Additional Information

Our Adrenaclick (epinephrine) Auto-injector Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Adrenaclick Consumer Information

Before using epinephrine, tell your doctor if any past use of this medicine caused an allergic reaction to get worse.

Call your doctor at once if you notice pain, swelling, warmth, redness, or other signs of infection around the area where you gave an injection.

Side effects may be more likely in older adults.

Common side effects may include:

  • breathing problems;
  • fast, irregular, or pounding heartbeats;
  • pale skin, sweating;
  • nausea and vomiting;
  • dizziness;
  • weakness or tremors;
  • headache; or
  • feeling restless, fearful, nervous, anxious, or excited.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Allergies can best be described as: See Answer
Adrenaclick Professional Information


Due to the lack of randomized, controlled clinical trials of epinephrine for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of epinephrine is difficult to determine. Adverse reactions reported in observational trials, case reports, and studies are listed below.

Common adverse reactions to systemically administered epinephrine include anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache; and/or respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with hypertension or hyperthyroidism [see WARNINGS AND PRECAUTIONS].

Cardiovascular Reactions
  • Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs [see WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS].
  • Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease [see WARNINGS AND PRECAUTIONS].
  • Angina may occur in patients with coronary artery disease [see WARNINGS AND PRECAUTIONS].
  • Rare cases of stress cardiomyopathy have been reported in patients treated with epinephrine.
Reactions From Accidental Injection And/Or Improper Technique
  • Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area [see WARNINGS AND PRECAUTIONS].
  • Adverse reactions experienced as a result of accidental injections may include increased heart rate, local reactions including injection site pallor, coldness and hypoesthesia or injury at the injection site resulting in bruising, bleeding, discoloration, erythema or skeletal injury.
  • Lacerations, bent needles, and embedded needles have been reported when Adrenaclick has been injected into the thigh of young children who are uncooperative and kick or move during an injection [see WARNINGS AND PRECAUTIONS].
  • Injection into the buttock has resulted in cases of gas gangrene [see WARNINGS AND PRECAUTIONS].
Skin And Soft Tissue Infections
  • Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported following epinephrine injection in the thigh [see WARNINGS AND PRECAUTIONS].

Read the entire FDA prescribing information for Adrenaclick (Epinephrine Injection, USP Auto-injector)

© Adrenaclick Patient Information is supplied by Cerner Multum, Inc. and Adrenaclick Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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