Aggrenox vs. Xarelto

Are Aggrenox and Xarelto the Same Thing?

Aggrenox (tadalafil) and Xarelto (sildenafil) are phosphodiesterase-5 (PDE5) inhibitors used for treating impotence (erectile dysfunction, or ED).

What Are Possible Side Effects of Aggrenox?

Common side effects of Aggrenox include:

What Are Possible Side Effects of Xarelto?

Common side effects of Xarelto include:

  • warmth or redness in the face, neck, or chest,
  • stuffy nose,
  • headaches,
  • stomach pain,
  • upset stomach,
  • nausea,
  • diarrhea,
  • memory problems,
  • back pain,
  • an inability to differentiate between the colors green and blue,
  • loss of hearing,
  • ringing in the ears,
  • and dizziness.

What is Aggrenox?

Aggrenox is a prescription medicine taken by mouth for the treatment of:

What is Xarelto?

Xarelto is a prescription medicine used to treat erectile dysfunction (ED). You will not get an erection just by taking this medicine. Xarelto helps a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated).

Xarelto is not for use in women or children.

It is not known if Xarelto is safe and effective in women or children under 18 years of age.


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What Drugs Interact With Aggrenox?

Do not take Aggrenox if you:

  • take any medicines called "nitrates".
  • use recreational drugs called "poppers" like amyl nitrite and butyl nitrite.
  • take any medicines called guanylate cyclase stimulators, such as riociguat.
  • are allergic to Aggrenox or Adcirca, or any of its ingredients.

Call your healthcare provider or get help right away if you have any of the symptoms of an allergic reaction listed above.

What Drugs Interact With Xarelto?

Do not take Xarelto if you:

  • take medicines called nitrates (such as nitroglycerin)
  • use street drugs called "poppers" such as amyl nitrate or amyl nitrite, and butyl nitrate
  • take any medicines called guanylate cyclase stimulators such as riociguat (Adempas)
  • are allergic to sildenafil, as contained in Xarelto and REVATIO, or any of the ingredients in Xarelto. See the end of this leaflet for a complete list of ingredients in Xarelto.

Tell your healthcare provider about all the medicines you take1, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Xarelto may affect the way other medicines work, and other medicines may affect the way Xarelto works causing side effects. Especially tell your healthcare provider if you take any of the following:

Xarelto contains sildenafil, which is the same medicine found in another drug called REVATIO. REVATIO is used to treat a rare disease called pulmonary arterial hypertension (PAH). Xarelto should not be used with REVATIO or with other PAH treatments containing sildenafil or any other PDE5 inhibitors (such as Adcirca [tadalafil]).

Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.

Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.

How Should Aggrenox Be Taken?

Take Aggrenox exactly as your healthcare provider prescribes it. Your healthcare provider will prescribe the dose that is right for you.

Some men can only take a low dose of Aggrenox or may have to take it less often, because of medical conditions or medicines they take.

Do not change your dose or the way you take Aggrenox without talking to your healthcare provider. Your healthcare provider may lower or raise your dose, depending on how your body reacts to Aggrenox and your health condition.

Aggrenox may be taken with or without meals.

If you take too much Aggrenox, call your healthcare provider or emergency room right away.

How Should Xarelto Be Taken?

Take Xarelto exactly as your healthcare provider tells you to take it.

Your healthcare provider will tell you how much Xarelto to take and when to take it.

Your healthcare provider may change your dose if needed.

Take Xarelto about 1 hour before sexual activity. You may take Xarelto between 30 minutes to 4 hours before sexual activity if needed.

Xarelto can be taken with or without food. If you take Xarelto after a high fat meal (such as a cheeseburger and french fries), Xarelto may take a little longer to start working

Do not take Xarelto more than 1 time a day.

If you accidentally take too much Xarelto, call your doctor or go to the nearest hospital emergency room right away.


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Aggrenox Prescribing Information.
Xarelto Prescribing Information.

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