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Last reviewed on RxList: 12/15/2018
AK-Pentolate Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 12/15/2018

AK-Pentolate (cyclopentolate hydrochloride ophthalmic solution) is an anticholinergic used to dilated the pupils (to produce mydriasis and cycloplegia). Common side effects of AK-Pentolate include:

Instill a dose of one or two drops of 1% or 2% AK-Pentolate solution in the eye, which may be repeated in five to ten minutes if necessary. AK-Pentolate may interact with carbachol, pilocarpine, or ophthalmic cholinesterase inhibitors. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using AK-Pentolate; it is unknown how it would affect a fetus. It is unknown if AK-Pentolate passes into breast milk. Consult your doctor before breastfeeding.

Our AK-Pentolate (cyclopentolate hydrochloride ophthalmic solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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AK-Pentolate Professional Information



Increased intraocular pressure, burning, photophobia, blurred vision, irritation, hyperemia, conjunctivitis, blepharoconjunctivitis, punctate keratitis, synechiae have been reported.


Use of cyclopentolate has been associated with psychotic reactions and behavioral disturbances, usually in children, especially with 2% concentration. These disturbances include ataxia, incoherent speech, restlessness, hallucinations, hyperactivity, seizures, disorientation as to time and place, and failure to recognize people. This drug produces reactions similar to those of other anticholinergic drugs, but the central nervous system manifestations as noted above are more common. Other manifestations of anticholinergic drugs are skin rash, abdominal distention in infants, unusual drowsiness, tachycardia, hyperpyrexia, vasodilation, urinary retention, diminished gastrointestinal motility and decreased secretion in salivary and sweat glands, pharynx, bronchi and nasal passages. Severe manifestations of toxicity include coma, medullary paralysis and death.

Read the entire FDA prescribing information for AK-Pentolate (Cyclopentolate Hydrochloride Ophthalmic Solution)


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© AK-Pentolate Patient Information is supplied by Cerner Multum, Inc. and AK-Pentolate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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