Medical Editor: John P. Cunha, DO, FACOEP
Akineton (biperiden hydrochloride) Tablet is an anticholinergic antiparkinson agent used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. Akineton is also used to treat and prevent these same muscular conditions when they are caused by drugs such as chlorpromazine, fluphenazine, perphenazine, and others. Common side effects of Akineton include:
- dry mouth/nose/throat,
- blurred vision,
- euphoria or disorientation,
- urinary retention,
- dizziness when standing up,
- disturbed behavior,
- decreased sweating,
- difficult or painful urination,
- involuntary movements,
- slow heart rate, and
- a reduction in rapid eye movement (REM) sleep.
The usual starting dose of Akineton to treat Parkinson's disease is one tablet taken orally three or four times daily. The dosage is individualized and may be increased to a maximum of 8 tablets (16 mg) per 24 hours. To treat drug-induced extrapyramidal symptoms, the dose is one tablet one to three times daily. Akineton may interact with narcotic pain relievers, phenothiazines and other antipsychotic medications, tricyclic antidepressants, antiarrhythmics, or antihistamines. Tell your doctor all medications you are taking. Akineton should be given during pregnancy only if prescribed. It is not known whether this drug is passed in breast milk. Consult your doctor before breastfeeding.
Our Akineton (biperiden hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Akineton (Biperiden)
Atropine-like side effects such as dry mouth; blurred vision; drowsiness; euphoria or disorientation; urinary retention; postural hypotension; constipation; agitation; disturbed behavior may been seen. A case of generalized choreic movements has been reported in a Parkinson's disease patient when biperiden was added to carbidopa/levodopa. A reduction in rapid eye movement (REM) sleep, characterized by increased REM latency and decreased percentage of REM sleep, has been reported. There usually are no significant changes in blood pressure or heart rate in patients who have been given the parenteral form of AKINETON (biperiden) . Mild transient postural hypotension and bradycardia may occur. These side effects can be minimized or avoided by slow intravenous administration. No local tissue reactions have been reported following intramuscular injection. If gastric irritation occurs following oral administration, it can be avoided by administering the drug during or after meals.
The central anticholinergic syndrome can occur as an adverse reaction to properly prescribed anticholinergic medication. See OVERDOSAGE section for signs and symptoms of the central anticholinergic syndrome, and for treatment.
Read the entire FDA prescribing information for Akineton (Biperiden)